Ingredient Dictionary

1,2,4-TRIHYDROXYBENZENE

Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4.

Definition

Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.

Source: PubChem

US FDA substance register · UNII 173O8B04RD · registered name 1,2,4-TRIHYDROXYBENZENE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

1,2,4-Trihydroxybenzene is the phenol that conforms to the formula:

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: ASEAN · European Union · South Korea · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1642

Source: EU prohibited substances (Annex II)

SCCS opinion: Opinion on 1,2,4-Trihydroxybenzene; OPINION ON hair dye 1,2,4-trihydroxybenzene (1,2,4-THB) COLIPA n° A33 (CAS 533-73-3) - Submission VI

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report: Safety Assessment of 1,2,4-Trihydroxybenzene as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name １，２，４－トリヒドロキシベンゼン: 本品は、次の化学式で表されるフェノールである。

Source: JCIA labelling names (Japan)

Names & identifiers

1,2,4-TRIHYDROXYBENZENEINCI1,2,4-트라이하이드록시벤젠Korean label name (MFDS standard)１，２，４－トリヒドロキシベンゼンJapanese labelling name

CAS No.chemical registry number: 533-73-3
EC No.EU chemical inventory number: 208-575-1
DTXSIDUS EPA chemical ID: DTXSID3040930
DTXCIDUS EPA compound ID: DTXCID1020930

IUPAC: Benzene-1,2,4-triol
Molecular formula: C6H6O3
Molecular weight: 126.111 g/mol

Measured properties

Appearance: solid
Melting/freezing point: 140.5 ℃
Vapour pressure: 0.00016 ㎜Hg(25℃)
Water solubility: 122000 ㎎/ℓ(Water Solubility 25℃)
Vapour density: 4.4
n-Octanol/water partition coefficient (Kow): 0.550
Molecular weight: 126.110

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 0 eye studies are on record.

Classed as moderate2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

SkinSens1
Skin Sensitization · QSAR Predicted
SkinIrr2
Skin Irritation · QSAR Predicted