What is this ingredient?

미국 FDA 물질 등록 · UNII 7XOO2LE6G3 · 등록명 1,4-Butanediol · 단일 화학물질

Are there usage precautions?

보습제, 피부 유연제 (추천 피부타입: 모든피부타입)

Ingredient Dictionary

1,4-BUTANEDIOL

Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group.

Definition

US FDA substance register · UNII 7XOO2LE6G3 · registered name 1,4-Butanediol · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Butane-1,4-diol is a butanediol that is butane in which one hydrogen of each of the methyl groups is substituted by a hydroxy group. A colourless, water-miscible, viscous liquid at room temperature (m.p. 16C) with a high boiling point (230C), it is mainly used for the production of other organic chemicals, particularly the solvent oxolane (also known as tetrahydrofuran or THF). It has a role as a protic solvent, a prodrug and a neurotoxin. It is a glycol and a butanediol.

Source: PubChem

1,4-Butanediol is the organic compound that conforms to the formula

Cosmetic roles

Base that dissolves other ingredientsSOLVENT

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Safety Assessment of Alkane Diols as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name １，４－ブタンジオール: 本品は、次の化学式で表される有機化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

1,4-BUTANEDIOLINCI1,4-부탄다이올Korean label name (MFDS standard)１，４－ブタンジオールJapanese labelling name

CAS No.chemical registry number: 110-63-4
EC No.EU chemical inventory number: 203-786-5
DTXSIDUS EPA chemical ID: DTXSID2024666
DTXCIDUS EPA compound ID: DTXCID804666

IUPAC: Butane-1,4-diol
Molecular formula: C4H10O2
Molecular weight: 90.122 g/mol

Measured properties

Appearance: liquid
Colour: colourless
Melting/freezing point: 19~20 ℃
Initial boiling point and range: 228 ℃
Flash point: &amp, gt, 121 ℃ ((o.c.))
Upper/lower flammability or explosive limits: 18.3 / 1.95 %
Vapour pressure: 0.0105 ㎜Hg ((25 ℃))
Vapour density: 3.1
Relative density: 1.017
n-Octanol/water partition coefficient (Kow): -0.83
Auto-ignition temperature: 350 ℃
Viscosity: 84.9 cP ((20 ℃))
Molecular weight: 90.12

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 32 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Processing aids not otherwise specified10
Monomers5
Solvent4
Intermediate3
Plasticizer3
Propellants, non-motive (blowing agents)1
Soil amendments1
Filler1

4 other uses

Chemical reaction regulator1
Hardener1
Binder1
Elasticizer1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

1 skin studies and 1 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 2 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Draize, et. al., J Pharm Exp Ther 82, 377-390, 1994 according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: Draize, et. al., J Pharm Exp Ther 82. 377-390, 1994 according to