Ingredient Dictionary

1,6-HEXANEDIAMINE

Hexane-1,6-diamine is a C6 alkane-alpha,-diamine.

Definition

Hexane-1,6-diamine is a C6 alkane-alpha,-diamine. It has a role as a human xenobiotic metabolite. It derives from a hydride of a hexane.

Source: PubChem

US FDA substance register · UNII ZRA5J5B2QW · registered name HEXAMETHYLENEDIAMINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps pH steadyBUFFERING

Safety & regulatory references

Korea’s toxic-substance GHS classification: Danger · H302 (category 4) · H312 (category 4) · H314 (category 1B) · +1 more

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

1,6-HEXANEDIAMINEINCI

CAS No.chemical registry number: 124-09-4
EC No.EU chemical inventory number: 204-679-6
DTXSIDUS EPA chemical ID: DTXSID5024922
DTXCIDUS EPA compound ID: DTXCID604922

IUPAC: Hexane-1,6-diamine
Molecular formula: C6H16N2
Molecular weight: 116.208 g/mol

Measured properties

Appearance: Hexamethylenediamine, solid is a colorless crystalline solid. It is soluble in water. It is corrosive to metals and tissue. Produces toxic oxides of nitrogen during combustion. · Hexamethylenediamine, solution appears as a clear colorless liquid. Burns although some effort is required to ignite. Soluble in water. Corrosive to metals and tissue. Produces toxic oxides of nitrogen during combustion. Used to make nylon.
Odour: ODOR OF PIPERIDINE · Weak, fishy
Boiling point: 401 °F at 760 mmHg (NTP, 1992) · 205 °C
Melting point: 108 °F (NTP, 1992) · 42 °C
Solubility: greater than or equal to 100 mg/mL at 73 °F (NTP, 1992) · FREELY SOL IN WATER, SLIGHTLY SOL IN ALC, BENZENE
Density: (anhyd.) 0.799 at 140.0 °F (70% soln.) 0.933 at 20 °C (USCG, 1999) · (anhyd) 0.799 at 60 °C (liquid)
Stability: VAPORIZES READILY
Dissociation constant: pKb= 3.3, pKa= 10.7 · pKa = 11.02 (conjugate acid)
Melting/freezing point: 32 ℃
Initial boiling point and range: 199~205 ℃
Flash point: 85 ℃(c.c.)
Upper/lower flammability or explosive limits: 7.6 / 0.9 %
Vapour pressure: 200 ㎩ (50℃)
Vapour density: 3.8
Relative density: 0.93
Auto-ignition temperature: 305 ℃

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 9 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Monomers3
Intermediate2
Binder1
Chemical reaction regulator1
pH regulating agent1
Elasticizer1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 3 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 10 studies

Category 1
Skin Sensitization · Screening
Skin Corr. 1B
Skin Irritation · Authoritative
Category 8.2C (Category 1C)
Skin Irritation · Read Across
Skin corrosion/irritation - Category 1
Skin Irritation · Screening
Corrosive
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) equivalent or similar to
Category 1
Skin Irritation · Screening
Corrosive
skin irritation: in vivo · Screening · other guideline: Directive 92/69/EEC, B.4 equivalent or similar to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: 92/69/EEC, B.5 equivalent or similar to
Category 8.3A (Category 1)
Eye Irritation · Read Across
Category 1
Eye Irritation · Screening