1-naphthol is a naphthol carrying a hydroxy group at position 1.
Definición
1-naphthol is a naphthol carrying a hydroxy group at position 1. It has a role as a genotoxin and a human xenobiotic metabolite.
Fuente: PubChem
Registro de sustancias de la FDA (EE. UU.) · UNII 2A71EAQ389 · nombre registrado 1-Naphthol · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Prohibido
- Corea del Sur
- Restringido o prohibido
- Corea del Sur · Taiwán
- Restringido
- Reino Unido · Taiwán
Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Lista de ingredientes restringidos de Health Canada · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)
Argentina · Brasil
- Field of application and/or use : Oxidation dye for coloring hairs
- Maximum concentration permitted at final product : 2%
- Other limitations and requirements : In combination with hydrogen peroxide the maximum concentration in the product ready to use is 1%
- Use conditions and warnings that must appear on the label : May cause allergic reaction
Canadá
- Conditions of Use by product type : (a) In Hair dyes as an oxidizing colouring agent (b) In combination with hydrogen peroxide
- Maximum Concentration Permitted : (a) 2% (b) 1%
ASEAN
- Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0%. The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past
China
- Concentración máxima : 1%
Unión Europea
- Product Type, body parts : Hair dye substance in oxidative hair dye products
- Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1 % calculated as free base
- Wording of conditions of use and warnings : Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past
Unión Europea
- Product Type, body parts : Hair dye substance in oxidative hair dye products
- Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0%
- Wording of conditions of use and warnings : To be printed on the label: Hair colorants can cause severe allergic reactions.
Fuente: Información regulatoria cosmética del MFDS (Corea)
Sin clasificación en la lista GHS de sustancias tóxicas de Corea · sustancia química existente
Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 16 · se aplica a Hair dye substance in oxidative hair dye products
Restriction III/16 · Other restriction: ban substances that deplete the ozone layer
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010
Reviewed by CIR: Final Report on the Safety Assessment of 1-Naphthol
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres e identificadores
- CAS No.número de registro químico
- 90-15-3
- EC No.número de inventario químico de la UE
- 201-969-4
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID6021793
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID401793
- IUPAC
- Naphthalen-1-ol
- Fórmula molecular
- C10H8O
- Peso molecular
- 144.173 g/mol
Propiedades medidas
- Aspecto
- Large Crystals · Colorless or yellow solid, [Hawley] Darkens on exposure to light, [Merck Index] Colorless crystalline solid, [MSDSonline]
- Olor
- Phenolic odor
- Punto de ebullición
- 288 °C · 279.00 to 280.00 °C. @ 760.00 mm Hg
- Punto de fusión
- 96 °C · 94.00 to 95.00 °C. @ 760.00 mm Hg
- Solubilidad
- In water, 866 mg/L at 25 °C · Very soluble in ethanol and ether, soluble in acetone
- Densidad
- 1.0954 at 98.7 °C/4 °C · 1.0989 @ 99°C
- Estabilidad
- Water stability: stable at pH < or =6.5, increased transformation with increased pH. /from table/ · Darkens on exposure to air or light.
- Constante de disociación
- pKa = 9.34 at 25 °C
- Punto de fusión/congelación
- 96 ℃
- Punto inicial e intervalo de ebullición
- 288 ℃
- Punto de inflamación
- 125 ℃
- Límites superior/inferior de inflamabilidad o explosividad
- 5.0 / 0.8 %
- Presión de vapor
- 1.7 ㎜Hg (110℃)
- Solubilidad en agua
- 866 ㎎/ℓ (25℃)
- Densidad relativa
- 1.0954 (98.7℃/ 4℃)
- Coeficiente de reparto n-octanol/agua (Kow)
- 2.85
- Temperatura de autoignición
- 510 ℃
- Peso molecular
- 144.17
Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.
Fuente: PubChem · Fichas de datos de seguridad de KOSHA (Corea)
Para qué lo usan los productos
Usos de los 8 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Degradant/impurity (EPA)3
- Dye3
- Intermediate2
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 8 estudios en piel y 6 en ojos.
Las conclusiones de los estudios coinciden en general (100%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 14 estudios
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Skin irritation - category 2
Skin Irritation · Screening - Category 1
Skin Irritation · Screening - Category 6.3A (Category 2)
Skin Irritation · Read Across - Skin corrosion/irritation - Category 2
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Skin sensitisation - category 1
Skin Sensitization · Screening - Skin Irrit. 2
Skin Irritation · Authoritative - Eye Dam. 1
Eye Irritation · Authoritative - Eye damage - category 1
Eye Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Serious eye damage/eye irritation - Category 1
Eye Irritation · Screening
Fuente: Panel CompTox de la EPA
Literatura relacionada
- 7 Final Report on the Safety Assessment of 1-Naphthol · 1989
- Ranking skin‐sensitizing hair dye molecules according to their potency by the use of human cells · 2018
- Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers · 2005
- Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility. · 1997
- The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. · 1993
Bases de datos vinculadas 29
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4 5
- ChEBI
- ChEMBL
- Cosmetic Ingredient Review (CIR, EE. UU.) 2 3
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Dictámenes de seguridad del SCCS (UE) 2
- Directiva cosmética de la ASEAN
- Fichas de datos de seguridad de KOSHA (Corea)
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Ingredientes cosméticos de la FDA de Taiwán
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- Lista de ingredientes restringidos de Health Canada
- NIST Chemistry WebBook
- Normativa cosmética de la FDA de Taiwán
- Normativa cosmética del Reino Unido (OPSS)
- Panel CompTox de la EPA 2
- PubChem 2
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Registro GHS de sustancias tóxicas de Corea (NIER)
- Reglamento de cosméticos de la UE
- Sustancias restringidas UE (anexo III)
- Wikidata
- Wikipedia · coreano · inglés · japonés · chino