Gloshell
成分辞典

成分辞典

1-NAPHTHOL

1-naphthol is a naphthol carrying a hydroxy group at position 1.

分子構造

定義

1-naphthol is a naphthol carrying a hydroxy group at position 1. It has a role as a genotoxin and a human xenobiotic metabolite.

出典: PubChem

米国FDA 物質登録 · UNII 2A71EAQ389 · 登録名 1-Naphthol · 単一の化学物質

出典: 米国FDA 物質識別番号(UNII)

化粧品での役割

髪を染めるHAIR DYEING

安全性・規制情報

禁止
韓国
制限・禁止
韓国
制限
イギリス

出典: 韓国食薬処 化粧品規制情報 · ASEAN 化粧品指令 · EU 化粧品規則 · カナダ 禁止・制限成分リスト · 台湾FDA 化粧品成分 · 台湾FDA 化粧品規制 · 英国 化粧品規則

アルゼンチン · ブラジル

  • Field of application and/or use : Oxidation dye for coloring hairs
  • Maximum concentration permitted at final product : 2%
  • Other limitations and requirements : In combination with hydrogen peroxide the maximum concentration in the product ready to use is 1%
  • Use conditions and warnings that must appear on the label : May cause allergic reaction

カナダ

  • Conditions of Use by product type : (a) In Hair dyes as an oxidizing colouring agent (b) In combination with hydrogen peroxide
  • Maximum Concentration Permitted : (a) 2% (b) 1%

ASEAN

  • Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
  • Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0%. The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past

台湾

  • ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
  • ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
  • ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
  • ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
  • 用途 : 使用限制
  • 最大配合量 : 氧化性染髮產品 : 2%

中国

  • 最大配合量 : 1%

欧州連合

  • Product Type, body parts : Hair dye substance in oxidative hair dye products
  • Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1 % calculated as free base
  • Wording of conditions of use and warnings : Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past

欧州連合

  • Product Type, body parts : Hair dye substance in oxidative hair dye products
  • Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0%
  • Wording of conditions of use and warnings : To be printed on the label: Hair colorants can cause severe allergic reactions.

出典: 韓国食薬処 化粧品規制情報

韓国の有害物質GHS分類なし · 既存化学物質

出典: 韓国 有害物質GHS情報(環境公団)

EU化粧品規則 附属書III(制限物質) 第16項 · 適用 Hair dye substance in oxidative hair dye products

出典: EU 制限成分(附属書III)

Restriction III/16 · Other restriction: ban substances that deplete the ozone layer

出典: EU CosIng 成分リスト

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

出典: 米国CIR 安全性評価

Reviewed by CIR: Final Report on the Safety Assessment of 1-Naphthol

出典: 米国CIR 安全性評価

詳しい資料 — 表示名・識別番号・物性・試験記録・文献

別名・識別情報

1-NAPHTHOLINCI1-나프톨韓国の表示名(食薬処標準名)1-Naphthalenol別名1- NAPHTHALENOL別名1-NAPHTHOL, AND ITS SALTS別名
CAS No.化学物質登録番号
90-15-3
EC No.EU化学物質目録番号
201-969-4
DTXSID米国EPA化学物質番号
DTXSID6021793
DTXCID米国EPA化合物番号
DTXCID401793
IUPAC
Naphthalen-1-ol
分子式
C10H8O
分子量
144.173 g/mol

測定された物性

性状
Large Crystals · Colorless or yellow solid, [Hawley] Darkens on exposure to light, [Merck Index] Colorless crystalline solid, [MSDSonline]
臭い
Phenolic odor
沸点
288 °C · 279.00 to 280.00 °C. @ 760.00 mm Hg
融点
96 °C · 94.00 to 95.00 °C. @ 760.00 mm Hg
溶解性
In water, 866 mg/L at 25 °C · Very soluble in ethanol and ether, soluble in acetone
密度
1.0954 at 98.7 °C/4 °C · 1.0989 @ 99°C
安定性
Water stability: stable at pH < or =6.5, increased transformation with increased pH. /from table/ · Darkens on exposure to air or light.
解離定数
pKa = 9.34 at 25 °C
融点・凝固点
96 ℃
初留点および沸点範囲
288 ℃
引火点
125 ℃
燃焼・爆発範囲の上限/下限
5.0 / 0.8 %
蒸気圧
1.7 ㎜Hg (110℃)
溶解度
866 ㎎/ℓ (25℃)
比重
1.0954 (98.7℃/ 4℃)
n-オクタノール/水分配係数(Kow)
2.85
自然発火温度
510 ℃
分子量
144.17

物質そのものを測定した値です。安全保健公団(KOSHA)の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。

出典: PubChem · 韓国安全保健公団 SDS

製品が実際に使っている用途

米国EPAにこの成分を届け出た製品8件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。

  • Degradant/impurity (EPA)3
  • Dye3
  • Intermediate2

出典: 米国EPA CompTox

刺激・感作試験の記録

皮膚試験8件・眼試験6件の記録があります。

中程度と分類1件

試験の結論はおおむね一致しています(100%)。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。

試験14件をすべて見る
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Skin irritation - category 2
    Skin Irritation · Screening
  • Category 1
    Skin Irritation · Screening
  • Category 6.3A (Category 2)
    Skin Irritation · Read Across
  • Skin corrosion/irritation - Category 2
    Skin Irritation · Screening
  • Classification not possible
    Skin Sensitization · Screening
  • Skin sensitisation - category 1
    Skin Sensitization · Screening
  • Skin Irrit. 2
    Skin Irritation · Authoritative
  • Eye Dam. 1
    Eye Irritation · Authoritative
  • Eye damage - category 1
    Eye Irritation · Screening
  • Corrosive or Irritation Persists for &gt; 21 days
    eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to
  • Category 1
    Eye Irritation · Screening
  • Category 8.3A (Category 1)
    Eye Irritation · Read Across
  • Serious eye damage/eye irritation - Category 1
    Eye Irritation · Screening

出典: 米国EPA CompTox

関連文献

連携データベース 29