1-naphthol is a naphthol carrying a hydroxy group at position 1.
定义
1-naphthol is a naphthol carrying a hydroxy group at position 1. It has a role as a genotoxin and a human xenobiotic metabolite.
来源: PubChem
美国FDA 物质登记 · UNII 2A71EAQ389 · 登记名称 1-Naphthol · 单一化学物质
化妆品中的作用
安全与法规参考
- 禁用
- 韩国
- 限用·禁用
- 韩国
- 限用
- 英国
来源: 韩国食药处 化妆品法规信息 · 东盟化妆品指令 · 欧盟化妆品法规 · 加拿大禁用·限用成分清单 · 台湾FDA 化妆品成分 · 台湾FDA 化妆品法规 · 英国化妆品法规
阿根廷 · 巴西
- Field of application and/or use : Oxidation dye for coloring hairs
- Maximum concentration permitted at final product : 2%
- Other limitations and requirements : In combination with hydrogen peroxide the maximum concentration in the product ready to use is 1%
- Use conditions and warnings that must appear on the label : May cause allergic reaction
加拿大
- Conditions of Use by product type : (a) In Hair dyes as an oxidizing colouring agent (b) In combination with hydrogen peroxide
- Maximum Concentration Permitted : (a) 2% (b) 1%
东盟
- Field of application and/or use : Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0%. The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past
台湾
- ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
- ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
- ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
- ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
- 用途 : 使用限制
- 最大配合量 : 氧化性染髮產品 : 2%
中国
- 最大配合量 : 1%
欧盟
- Product Type, body parts : Hair dye substance in oxidative hair dye products
- Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1 % calculated as free base
- Wording of conditions of use and warnings : Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past
欧盟
- Product Type, body parts : Hair dye substance in oxidative hair dye products
- Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0%
- Wording of conditions of use and warnings : To be printed on the label: Hair colorants can cause severe allergic reactions.
来源: 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
欧盟化妆品法规 附录III(限用物质) 第16项 · 适用 Hair dye substance in oxidative hair dye products
来源: 欧盟限用成分(附录III)
Restriction III/16 · Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Report on the Safety Assessment of 1-Naphthol
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 90-15-3
- EC No.欧盟化学品目录编号
- 201-969-4
- DTXSID美国EPA化学品编号
- DTXSID6021793
- DTXCID美国EPA化合物编号
- DTXCID401793
- IUPAC
- Naphthalen-1-ol
- 分子式
- C10H8O
- 分子量
- 144.173 g/mol
实测物性
- 性状
- Large Crystals · Colorless or yellow solid, [Hawley] Darkens on exposure to light, [Merck Index] Colorless crystalline solid, [MSDSonline]
- 气味
- Phenolic odor
- 沸点
- 288 °C · 279.00 to 280.00 °C. @ 760.00 mm Hg
- 熔点
- 96 °C · 94.00 to 95.00 °C. @ 760.00 mm Hg
- 溶解性
- In water, 866 mg/L at 25 °C · Very soluble in ethanol and ether, soluble in acetone
- 密度
- 1.0954 at 98.7 °C/4 °C · 1.0989 @ 99°C
- 稳定性
- Water stability: stable at pH < or =6.5, increased transformation with increased pH. /from table/ · Darkens on exposure to air or light.
- 解离常数
- pKa = 9.34 at 25 °C
- 熔点/凝固点
- 96 ℃
- 初沸点和沸程
- 288 ℃
- 闪点
- 125 ℃
- 燃烧或爆炸范围上限/下限
- 5.0 / 0.8 %
- 蒸气压
- 1.7 ㎜Hg (110℃)
- 溶解度
- 866 ㎎/ℓ (25℃)
- 比重
- 1.0954 (98.7℃/ 4℃)
- 正辛醇/水分配系数(Kow)
- 2.85
- 自燃温度
- 510 ℃
- 分子量
- 144.17
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 8 款产品的用途。其中包括化妆品以外的产品,排在前几行的即为该成分的主要用途。
- Degradant/impurity (EPA)3
- Dye3
- Intermediate2
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 8 项、眼部试验 6 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 14 项试验
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Skin irritation - category 2
Skin Irritation · Screening - Category 1
Skin Irritation · Screening - Category 6.3A (Category 2)
Skin Irritation · Read Across - Skin corrosion/irritation - Category 2
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Skin sensitisation - category 1
Skin Sensitization · Screening - Skin Irrit. 2
Skin Irritation · Authoritative - Eye Dam. 1
Eye Irritation · Authoritative - Eye damage - category 1
Eye Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) according to - Category 1
Eye Irritation · Screening - Category 8.3A (Category 1)
Eye Irritation · Read Across - Serious eye damage/eye irritation - Category 1
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- 7 Final Report on the Safety Assessment of 1-Naphthol · 1989
- Ranking skin‐sensitizing hair dye molecules according to their potency by the use of human cells · 2018
- Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers · 2005
- Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility. · 1997
- The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. · 1993
关联数据库 29
- 澳大利亚工业化学品名录(AICIS)
- 东盟化妆品指令
- 韩国安全保健公团 安全数据表
- 韩国化妆品协会成分词典
- 韩国食药处 化妆品法规信息 2 3 4
- 韩国食药处 化妆品原料成分 2
- 韩国有毒物质 GHS 信息(环境公团)
- 加拿大禁用·限用成分清单
- 美国CIR 安全性评估 2 3
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 欧盟 CosIng 成分清单 2
- 欧盟 SCCS 安全意见 2
- 欧盟化妆品法规
- 欧盟限用成分(附录III)
- 台湾FDA 化妆品成分
- 台湾FDA 化妆品法规
- 英国化妆品法规
- 中国已使用化妆品原料目录(IECIC)
- ChEBI
- ChEMBL
- NIST 化学网络手册
- PubChem 2
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata
- Wikipedia · 韩语 · 英语 · 日语 · 中文