Safranal is a monoterpenoid formally derived from beta-cyclocitral by dehydrogenation.
Definition
Safranal is a monoterpenoid formally derived from beta-cyclocitral by dehydrogenation. It is the major volatile component of saffron responsible for the characteristic aroma of saffron. It has a role as an antineoplastic agent, a radical scavenger, a neuroprotective agent, an anti-inflammatory agent, a nephroprotective agent and a plant metabolite. It is functionally related to a beta-cyclocitral.
Source: PubChem
US FDA substance register · UNII 4393FR07EA · registered name SAFRANAL · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- International fragrance standard (IFRA)
Source: IFRA fragrance standards
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 116-26-7
- EC No.EU chemical inventory number
- 204-133-7
- DTXSIDUS EPA chemical ID
- DTXSID7049398
- DTXCIDUS EPA compound ID
- DTXCID4029357
- IUPAC
- 2,6,6-Trimethylcyclohexa-1,3-diene-1-carbaldehyde
- Molecular formula
- C10H14O
- Molecular weight
- 150.221 g/mol
Measured properties
- Appearance
- liquid
- Melting/freezing point
- 29.14 ℃
- Initial boiling point and range
- 70 ℃
- Flash point
- 84.9 ℃
- Vapour pressure
- 0.17 ㎜Hg
- Water solubility
- 514.9 ㎎/ℓ
- Vapour density
- 5.1853641698308595
- n-Octanol/water partition coefficient (Kow)
- 2.7
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient2
- Fragrance2
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · no guideline available other guideline: Guinea Pig Maximization Test, MAGNUSSON & KLIGMAN (1969, 1970, 1975) - SkinSens1
Skin Sensitization · QSAR Predicted - Low to Moderate Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · no guideline available other guideline: CTFA Safety testing guidelines - Severe Irritation
eye irritation: in vitro / ex vivo · Screening · OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants) [before 26 July 2013] according to
Source: US EPA CompTox dashboard
Linked databases 15
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- IFRA fragrance standards
- KOSHA safety data sheets (Korea)
- NIST Chemistry WebBook
- PubChem
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese