What is this ingredient?

미국 FDA 물질 등록 · UNII 283XH39M8X · 등록명 GLYCIDYLTRIMETHYLAMMONIUM CHLORIDE · 단일 화학물질

Ingredient Dictionary

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE

Definition

US FDA substance register · UNII 283XH39M8X · registered name GLYCIDYLTRIMETHYLAMMONIUM CHLORIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

2,3-Epoxypropyltrimoniium Chloride is the quaternary ammonium salt that conforms to the formula:

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Banned: ASEAN · European Union · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H412 (category 3) · H373 (category 2) · H361 (category 2) · +7 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1473

Source: EU prohibited substances (Annex II)

Restriction II/1473

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

2,3-EPOXYPROPYLTRIMONIIUM CHLORIDEINCIOxiranemethanaminium, N,N,N-trimethyl-, chlorideSynonym

CAS No.chemical registry number: 3033-77-0
EC No.EU chemical inventory number: 221-221-0
DTXSIDUS EPA chemical ID: DTXSID1044643
DTXCIDUS EPA compound ID: DTXCID9024643

IUPAC: N,N,N-Trimethyl-1-(oxiran-2-yl)methanaminium chloride
Molecular formula: C6H14ClNO
Molecular weight: 151.63 g/mol

Measured properties

Appearance: Liquid · COLOURLESS-TO-LIGHT-YELLOW CLEAR ODOURLESS LIQUID.
Solubility: Solubility in water: miscible
Density: 1.1 g/cm³
Initial boiling point and range: 110 ℃
Flash point: 170 ℃
Vapour pressure: &amp, lt, 0 hPa (22℃)
Vapour density: 1.13 g/㎤ (20℃)
Relative density: 1.18 (20℃)
n-Octanol/water partition coefficient (Kow): &amp, lt, (25℃, pH: 4)
Auto-ignition temperature: 400 ℃
Viscosity: 80 mPa S (20℃)

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Processing aids not otherwise specified1
No specific technical function1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Skin Sens. 1
Skin Sensitization · Authoritative
Sh
Skin Sensitization · Authoritative
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Eye Dam. 1
Eye Irritation · Authoritative