Ingredient Dictionary

2,5-XYLENOL

2,5-xylenol is a member of the class of phenols that phenol substituted by methyl groups at positions 2 and 5.

Definition

2,5-xylenol is a member of the class of phenols that phenol substituted by methyl groups at positions 2 and 5. It has a role as a volatile oil component and an animal metabolite. It derives from a hydride of a p-xylene.

Source: PubChem

US FDA substance register · UNII XH3E3564KX · registered name 2,5-XYLENOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Korea’s toxic-substance GHS classification: Danger · H317 (category 1) · H411 (category 2) · H311 (category 3) · +2 more

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

2,5-XYLENOLINCIPhenol, 2,5-dimethyl-Synonym

CAS No.chemical registry number: 95-87-4
EC No.EU chemical inventory number: 202-461-5
DTXSIDUS EPA chemical ID: DTXSID6025145
DTXCIDUS EPA compound ID: DTXCID905145

IUPAC: 2,5-Dimethylphenol
Molecular formula: C8H10O
Molecular weight: 122.167 g/mol

Measured properties

Appearance: 2,5-dimethylphenol is a colorless to off-white crystalline solid. Odor threshold concentration 0.4 mg/L. Taste threshold concentration 0.5 mg/L. (NTP, 1992) · Liquid, Dry Powder
Boiling point: 414 °F at 760 mmHg (NTP, 1992) · 211.5 °C @ 762 mm Hg
Melting point: 160 to 163 °F (NTP, 1992) · 74.5 °C
Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) · Sol in ethyl alcohol, very sol in ethyl ether, sl sol in chloroform
Density: 0.971 (NTP, 1992) - Less dense than water, will float · 0.965 AT 80 °C
Viscosity: 1.55 mN.s.m-2 at 80 °C · 1.55 Ns/㎡((80℃))
Dissociation constant: pKa= 10.41 at 25 °C · pK = 10.3
Melting/freezing point: 74.8 ℃
Initial boiling point and range: 211.1 ℃
Flash point: 87 ℃
Vapour pressure: 0.156 ㎜Hg
Water solubility: 3540 ㎎/ℓ (at 25 deg C)
Relative density: 0.97 ((80℃))
n-Octanol/water partition coefficient (Kow): 2.33
Auto-ignition temperature: 599
Molecular weight: 122.17

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 10 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Flavouring and nutrient3
Fragrance2
Cleaning agent2
Solvent2
Corrosion inhibitor1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as highly irritating1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

Category 8.2C (Category 1C)
Skin Irritation · Read Across
Classification not possible
Skin Sensitization · Screening
Skin Corr. 1B
Skin Irritation · Authoritative
Classification not possible
Skin Irritation · Screening
Category 8.3A (Category 1)
Eye Irritation · Read Across
Classification not possible
Eye Irritation · Screening