What is this ingredient?

미국 FDA 물질 등록 · UNII P8740PEW4B · 등록명 2-Amino-3-hydroxypyridine · 단일 화학물질

All ingredients

Ingredient Dictionary

2-AMINO-3-HYDROXYPYRIDINE

2-amino-3-hydroxypyridine is a monohydroxypyridine and an aminopyridine.

Korean limit: 1.0%

2-AMINO-3-HYDROXYPYRIDINE Molecular structure — Molecular structure

Definition

US FDA substance register · UNII P8740PEW4B · registered name 2-Amino-3-hydroxypyridine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

2-amino-3-hydroxypyridine is a monohydroxypyridine and an aminopyridine.

Source: PubChem

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Restricted: South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.0% The direction for use “wear suitable gloves” must be included in label or leaflet text.
Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

China

Maximum concentration : 0.3%

European Union

Product Type, body parts : Hair dye substance in oxidative hair dye products
Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,0%
Wording of conditions of use and warnings : To be printed on the label: The mixing ratio. ‘ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.’

Source: MFDS (Korea) cosmetic regulatory information

EU Cosmetics Regulation, Annex III (restricted substances), entry 211 · applies to (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes

Source: EU restricted substances (Annex III)

Restriction Annex III/211 - Directive 2012/21/EU · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on 2-Amino-3-hydroxypyridine

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of 2-Amino-3-Hydroxypyridine as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

2-AMINO-3-HYDROXYPYRIDINEINCI2-아미노-3-히드록시피리딘Korean label name (MFDS standard)3-Pyridinol, 2-amino-Synonym

CAS No.chemical registry number: 16867-03-1
EC No.EU chemical inventory number: 240-886-8
DTXSIDUS EPA chemical ID: DTXSID50168588
DTXCIDUS EPA compound ID: DTXCID4091079

IUPAC: 2-Aminopyridin-3-ol
Molecular formula: C5H6N2O
Molecular weight: 110.116 g/mol

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye3

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)
Category 6.4A (Category 2A)
Eye Irritation · Read Across