Ingredient Dictionary

2-AMINO-4-NITROPHENOL

2-Amino-4-nitrophenol is a member of 4-nitrophenols.

Definition

2-Amino-4-nitrophenol is a member of 4-nitrophenols.

Source: PubChem

US FDA substance register · UNII G501UCI6T9 · registered name 2-AMINO-4-NITROPHENOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 383

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/383

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

2-AMINO-4-NITROPHENOLINCI2-아미노-4-니트로페놀Korean label name (MFDS standard)Phenol, 2-amino-4-nitro-Synonym

CAS No.chemical registry number: 99-57-0
EC No.EU chemical inventory number: 202-767-9
DTXSIDUS EPA chemical ID: DTXSID6020062
DTXCIDUS EPA compound ID: DTXCID0062

IUPAC: 2-Amino-4-nitrophenol
Molecular formula: C6H6N2O3
Molecular weight: 154.125 g/mol

Measured properties

Appearance: solid
Melting/freezing point: 144 ℃
Vapour pressure: 352000 ㎜Hg
Water solubility: 925 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 1.26
Molecular weight: 154.13

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 0 eye studies are on record.

Classed as highly irritating2Classed as low1

The study conclusions largely agree (67%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

SkinSens1
Skin Sensitization · QSAR Predicted
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline:
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: according to