2-Amino-5-nitrophenol is a member of 3-nitrophenols.
Definition
2-Amino-5-nitrophenol is a member of 3-nitrophenols.
Source: PubChem
US FDA substance register · UNII 0149H05U82 · registered name 2-AMINO-5-NITROPHENOL · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 384
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/384 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 121-88-0
- DTXSIDUS EPA chemical ID
- DTXSID1020063
- DTXCIDUS EPA compound ID
- DTXCID2063
- IUPAC
- 2-Amino-5-nitrophenol
- Molecular formula
- C6H6N2O3
- Molecular weight
- 154.125 g/mol
Measured properties
- Appearance
- 2-amino-5-nitrophenol appears as brown amorphous granules or powder. Melting point 198-202 °C. · Olive-brown, brown, or orange solid, [HSDB] Green crystalline solid, [MSDSonline]
- Melting point
- 388 to 396 °F (decomposes) (NTP, 1992) · 205.8 °C
- Solubility
- less than 1 mg/mL at 68 °F (NTP, 1992) · Slightly soluble in water
- Melting/freezing point
- 205.8 ℃
- Initial boiling point and range
- 317.38 ℃
- Vapour pressure
- 0.00000271 ㎜Hg (at 20℃)
- Water solubility
- 10400 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 0.99
- Molecular weight
- 154.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
- Evaluation of skin irritation and sensitization of hair dye components, Resorcinol, 2-Amino-5-Nitrophenol 2-Nitro-p-Phenylenediamine and p-phenlyenediamine, and comparison between two commercial hair dye products using 3-Dimensional Reconstructed Human Epidermis Model, Keraskin · 2016
- Analysis of cosmetic products by gas chromatography/mass spectrometry and fast-atom bombardment mass spectrometry: when a combined approach is successful · 1997
Linked databases 24
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem 2
- Tlooto literature search 2
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata