Definición
Registro de sustancias de la FDA (EE. UU.) · UNII 0ZLP5I1TMC · nombre registrado 2-AMINO-6-CHLORO-4-NITROPHENOL · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Prohibido
- Corea del Sur
- Restringido o prohibido
- Corea del Sur · Taiwán
- Restringido
- Reino Unido · Taiwán
Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)
ASEAN
- Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Maximum authorised concentration in the finished cosmetic product : (b) 2.0 %
- Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows
China
- Concentración máxima : 1%
- Concentración máxima : 2%
Unión Europea
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
- Maximum concentration in ready for use preparation : (b) 2.0%
- Other : (a) After mixing under oxidative conditions the maximum concentraion applied to hair must not exceed 2.0%
- Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna†tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna†tattoo in the past. (b) ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna†tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna†tattoo in the past.’
Fuente: Información regulatoria cosmética del MFDS (Corea)
Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 252 · concentración máxima (b) 2.0% · se aplica a (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
Restriction III/252 · Other restriction: ban substances that deplete the ozone layer
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
Reviewed by CIR: Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres y definiciones oficiales
Nombre de etiquetado de la JCIA 2-アミノ-6-クロロ-4-ニトロフェノール: 本品は、次の化学式で表される芳香族アミンである。
Nombres e identificadores
- CAS No.número de registro químico
- 6358-09-4
- EC No.número de inventario químico de la UE
- 228-762-1
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID9043855
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID7023855
- IUPAC
- 2-Amino-6-chloro-4-nitrophenol
- Fórmula molecular
- C6H5ClN2O3
- Peso molecular
- 188.57 g/mol
Para qué lo usan los productos
Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Dye3
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 4 estudios en piel y 3 en ojos.
Los estudios no coinciden (la conclusión más frecuente reúne el 33%), así que no demuestran que el ingrediente sea irritante. Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 7 estudios
- SkinSens1
Skin Sensitization · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) Deviations, reliability, and validity evaluated against current OECD 404 (Apr. 24, 2002) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) according to - Severe Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Low concentration used, not in accordance with REACh requirement. according to
Fuente: Panel CompTox de la EPA
Literatura relacionada
Bases de datos vinculadas 22
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto
- Cosmetic Ingredient Review (CIR, EE. UU.) 2 3
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Dictámenes de seguridad del SCCS (UE)
- Directiva cosmética de la ASEAN
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Ingredientes cosméticos de la FDA de Taiwán
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- Nombres de etiquetado de la JCIA (Japón)
- Normativa cosmética de la FDA de Taiwán
- Normativa cosmética del Reino Unido (OPSS)
- Panel CompTox de la EPA 2
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Reglamento de cosméticos de la UE
- Sustancias restringidas UE (anexo III)
- Wikidata