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Ingredientes

Diccionario de ingredientes

2-AMINO-6-CHLORO-4-NITROPHENOL

Estructura molecular

Definición

Registro de sustancias de la FDA (EE. UU.) · UNII 0ZLP5I1TMC · nombre registrado 2-AMINO-6-CHLORO-4-NITROPHENOL · sustancia química única

Fuente: Identificador único de ingredientes de la FDA (UNII)

Funciones cosméticas

Tiñe el cabelloHAIR DYEING

Referencias de seguridad y regulación

Prohibido
Corea del Sur
Restringido o prohibido
Corea del Sur · Taiwán
Restringido
Reino Unido · Taiwán

Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)

ASEAN

  • Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
  • Maximum authorised concentration in the finished cosmetic product : (b) 2.0 %
  • Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows

China

  • Concentración máxima : 1%
  • Concentración máxima : 2%

Unión Europea

  • Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
  • Maximum concentration in ready for use preparation : (b) 2.0%
  • Other : (a) After mixing under oxidative conditions the maximum concentraion applied to hair must not exceed 2.0%
  • Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past. (b) ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna” tattoo in the past.’

Fuente: Información regulatoria cosmética del MFDS (Corea)

Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 252 · concentración máxima (b) 2.0% · se aplica a (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products

Fuente: Sustancias restringidas UE (anexo III)

Restriction III/252 · Other restriction: ban substances that deplete the ozone layer

Fuente: Lista de ingredientes CosIng (UE)

Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Reviewed by CIR: Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Más datos: nombres, identificadores, propiedades, ensayos y literatura

Nombres y definiciones oficiales

Nombre de etiquetado de la JCIA 2-アミノ-6-クロロ-4-ニトロフェノール: 本品は、次の化学式で表される芳香族アミンである。

Fuente: Nombres de etiquetado de la JCIA (Japón)

Nombres e identificadores

2-AMINO-6-CHLORO-4-NITROPHENOLINCI2-아미노-6-클로로-4-니트로페놀Nombre en etiquetas coreanas (estándar MFDS)Phenol, 2-amino-6-chloro-4-nitro-Sinónimo2-アミノ-6-クロロ-4-ニトロフェノールNombre de etiquetado japonés
CAS No.número de registro químico
6358-09-4
EC No.número de inventario químico de la UE
228-762-1
DTXSIDidentificador químico de la EPA (EE. UU.)
DTXSID9043855
DTXCIDidentificador de compuesto de la EPA (EE. UU.)
DTXCID7023855
IUPAC
2-Amino-6-chloro-4-nitrophenol
Fórmula molecular
C6H5ClN2O3
Peso molecular
188.57 g/mol

Para qué lo usan los productos

Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.

  • Dye3

Fuente: Panel CompTox de la EPA

Estudios de irritación y sensibilización

Constan 4 estudios en piel y 3 en ojos.

Clasificado como muy irritante1Clasificado como bajo2

Los estudios no coinciden (la conclusión más frecuente reúne el 33%), así que no demuestran que el ingrediente sea irritante. Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.

Ver los 7 estudios
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • Studies Indicate No Significant Irritation
    skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) Deviations, reliability, and validity evaluated against current OECD 404 (Apr. 24, 2002) according to
  • Not likely to be sensitizing
    skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
  • Ambiguous
    eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) according to
  • Severe Irritation
    eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to
  • Studies Indicate No Significant Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Low concentration used, not in accordance with REACh requirement. according to

Fuente: Panel CompTox de la EPA

Literatura relacionada

Bases de datos vinculadas 22