2-AMINO-6-CHLORO-4-NITROPHENOL
定義
米国FDA 物質登録 · UNII 0ZLP5I1TMC · 登録名 2-AMINO-6-CHLORO-4-NITROPHENOL · 単一の化学物質
化粧品での役割
安全性・規制情報
- 禁止
- 韓国
- 制限・禁止
- 韓国
- 制限
- イギリス
出典: 韓国食薬処 化粧品規制情報 · ASEAN 化粧品指令 · EU 化粧品規則 · 台湾FDA 化粧品成分 · 台湾FDA 化粧品規制 · 英国 化粧品規則
ASEAN
- Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Maximum authorised concentration in the finished cosmetic product : (b) 2.0 %
- Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows
台湾
- ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
- ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
- ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
- ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
- 用途 : 使用限制
- 最大配合量 : (a)氧化性染髮產品 : 2%
- (b)非氧化性染髮產品 : 2%
中国
- 最大配合量 : 1%
- 最大配合量 : 2%
欧州連合
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
- Maximum concentration in ready for use preparation : (b) 2.0%
- Other : (a) After mixing under oxidative conditions the maximum concentraion applied to hair must not exceed 2.0%
- Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna†tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna†tattoo in the past. (b) ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna†tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna†tattoo in the past.’
出典: 韓国食薬処 化粧品規制情報
EU化粧品規則 附属書III(制限物質) 第252項 · 最大濃度 (b) 2.0% · 適用 (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
出典: EU 制限成分(附属書III)
Restriction III/252 · Other restriction: ban substances that deplete the ozone layer
出典: EU CosIng 成分リスト
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
出典: 米国CIR 安全性評価
Reviewed by CIR: Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
出典: 米国CIR 安全性評価
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
公式表示名・定義
日本化粧品工業会の表示名称 2-アミノ-6-クロロ-4-ニトロフェノール: 本品は、次の化学式で表される芳香族アミンである。
出典: 日本化粧品工業会 表示名称
別名・識別情報
- CAS No.化学物質登録番号
- 6358-09-4
- EC No.EU化学物質目録番号
- 228-762-1
- DTXSID米国EPA化学物質番号
- DTXSID9043855
- DTXCID米国EPA化合物番号
- DTXCID7023855
- IUPAC
- 2-Amino-6-chloro-4-nitrophenol
- 分子式
- C6H5ClN2O3
- 分子量
- 188.57 g/mol
製品が実際に使っている用途
刺激・感作試験の記録
皮膚試験4件・眼試験3件の記録があります。
試験ごとに結論が分かれています(最も多い結論の割合 33%)。この成分が刺激性だとは言い切れないということです。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。
試験7件をすべて見る
- SkinSens1
Skin Sensitization · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) Deviations, reliability, and validity evaluated against current OECD 404 (Apr. 24, 2002) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) according to - Severe Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Low concentration used, not in accordance with REACh requirement. according to
出典: 米国EPA CompTox
関連文献
連携データベース 22
- ASEAN 化粧品指令
- EU CosIng 成分リスト 2
- EU SCCS 安全性意見
- EU 化粧品規則
- EU 制限成分(附属書III)
- Tlooto 学術文献検索
- UniChem 化学物質統合ID
- Wikidata
- オーストラリア 化学物質リスト(AICIS)
- 英国 化粧品規則
- 韓国食薬処 化粧品規制情報 2 3 4
- 韓国食薬処 化粧品原料成分 2
- 台湾FDA 化粧品規制
- 台湾FDA 化粧品成分
- 大韓化粧品協会 成分辞典
- 中国 既存化粧品原料リスト(IECIC)
- 日本化粧品工業会 表示名称
- 米国CIR 安全性評価 2 3
- 米国EPA CompTox 2
- 米国EPA 化学物質DB(DSSTox)
- 米国FDA 物質識別番号(UNII)
- 米国FDA 物質登録(GSRS)