定义
美国FDA 物质登记 · UNII 0ZLP5I1TMC · 登记名称 2-AMINO-6-CHLORO-4-NITROPHENOL · 单一化学物质
化妆品中的作用
安全与法规参考
- 禁用
- 韩国
- 限用·禁用
- 韩国
- 限用
- 英国
来源: 韩国食药处 化妆品法规信息 · 东盟化妆品指令 · 欧盟化妆品法规 · 台湾FDA 化妆品成分 · 台湾FDA 化妆品法规 · 英国化妆品法规
东盟
- Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Maximum authorised concentration in the finished cosmetic product : (b) 2.0 %
- Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 % (a) and (b): The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (a) & (b) Do not use to dye eyelashes or eyebrows
台湾
- ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
- ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
- ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
- ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
- 用途 : 使用限制
- 最大配合量 : (a)氧化性染髮產品 : 2%
- (b)非氧化性染髮產品 : 2%
中国
- 最大配合量 : 1%
- 最大配合量 : 2%
欧盟
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
- Maximum concentration in ready for use preparation : (b) 2.0%
- Other : (a) After mixing under oxidative conditions the maximum concentraion applied to hair must not exceed 2.0%
- Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna†tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna†tattoo in the past. (b) ‘ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna†tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary “black henna†tattoo in the past.’
来源: 韩国食药处 化妆品法规信息
欧盟化妆品法规 附录III(限用物质) 第252项 · 最高浓度 (b) 2.0% · 适用 (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products
来源: 欧盟限用成分(附录III)
Restriction III/252 · Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
官方标示名称和定义
日本化妆品工业联合会标示名称 2-アミノ-6-クロロ-4-ニトロフェノール: 本品は、次の化学式で表される芳香族アミンである。
来源: 日本化妆品工业联合会标示名称
别名和识别信息
- CAS No.化学物质登记号
- 6358-09-4
- EC No.欧盟化学品目录编号
- 228-762-1
- DTXSID美国EPA化学品编号
- DTXSID9043855
- DTXCID美国EPA化合物编号
- DTXCID7023855
- IUPAC
- 2-Amino-6-chloro-4-nitrophenol
- 分子式
- C6H5ClN2O3
- 分子量
- 188.57 g/mol
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 4 项、眼部试验 3 项。
各项试验结论不一(最多的结论占 33%),因此不能断定该成分有刺激性。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 7 项试验
- SkinSens1
Skin Sensitization · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) Deviations, reliability, and validity evaluated against current OECD 404 (Apr. 24, 2002) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) - Ambiguous
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage) according to - Severe Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) Low concentration used, not in accordance with REACh requirement. according to
来源: 美国EPA CompTox
相关文献
关联数据库 22
- 澳大利亚工业化学品名录(AICIS)
- 东盟化妆品指令
- 韩国化妆品协会成分词典
- 韩国食药处 化妆品法规信息 2 3 4
- 韩国食药处 化妆品原料成分 2
- 美国CIR 安全性评估 2 3
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 欧盟 CosIng 成分清单 2
- 欧盟 SCCS 安全意见
- 欧盟化妆品法规
- 欧盟限用成分(附录III)
- 日本化妆品工业联合会标示名称
- 台湾FDA 化妆品成分
- 台湾FDA 化妆品法规
- 英国化妆品法规
- 中国已使用化妆品原料目录(IECIC)
- Tlooto 学术文献检索
- UniChem 化学物质统一 ID
- Wikidata