Bronopol is a nitro compound.
- Korean limit
- 0.10%
Definition
Bronopol is a nitro compound.
Source: PubChem
US FDA substance register · UNII 6PU1E16C9W · registered name BRONOPOL · single chemical substance
2-Bromo-2-Nitropropane-1,3-Diol is a substituted aliphatic diol that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Allowed preservative
- United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Argentina · Brazil
- Maximum concentration permitted at final product : 0.1%
- Other limitations and requirements : Avoid formation of nitrosamines
ASEAN
- Maximum authorised concentration in the finished cosmetic product : 0.1%
- Other limitations and requirements : Avoid formation of nitrosamines
Canada
- Conditions of Use by product type : (a) Not permitted in cosmetics that contain amines or amides. (b) Other cosmetics
- Maximum Concentration Permitted : (b) 0.1%
Taiwan
- Maximum concentration : 0.1%
- 0.1%
China
- Maximum concentration : 0.1%
South Korea
- Maximum concentration : 0.10%
European Union
- Maximum concentration in ready for use preparation : 0.1%
- Other : Avoid formation of nitrosamines
Source: MFDS (Korea) cosmetic regulatory information
Korea’s toxic-substance GHS classification: Danger · H331 (category 3) · H315 (category 2) · H318 (category 1) · +5 more
EU Cosmetics Regulation, Annex V (allowed preservatives), entry 21 · maximum concentration 0.1%
Restriction V/21 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances
Source: EU CosIng ingredient list
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005
Reviewed by CIR: Addendum to the Final Report on the Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol (JEPT 4(4) 47-61 1980)
Reviewed by CIR: Revised Tentative Report: Amended Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol as Used in Cosmetics
Reviewed by CIR: Final Report of the Safety Assessment for 2-Bromo-2-Nitropropane-1,3-Diol
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 52-51-7
- EC No.EU chemical inventory number
- 200-143-0
- DTXSIDUS EPA chemical ID
- DTXSID8024652
- DTXCIDUS EPA compound ID
- DTXCID904652
- IUPAC
- 2-Bromo-2-nitropropane-1,3-diol
- Molecular formula
- C3H6BrNO4
- Molecular weight
- 199.988 g/mol
Measured properties
- Appearance
- solid
- Colour
- white
- Odour
- odourless
- Melting/freezing point
- 120~122 ℃
- Initial boiling point and range
- 388 ℃
- Flash point
- 170 ℃
- Upper/lower flammability or explosive limits
- - / -
- Vapour pressure
- 0.0000126 ㎜Hg(at 20C)
- Water solubility
- 0.028 g/100㎖(at 22~25 °C)
- Relative density
- 1.9 (at 20 °C)
- n-Octanol/water partition coefficient (Kow)
- 0.18 (at 25 °C)
- Molecular weight
- 199.99
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 162 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Preservative131
- Biocide16
- No specific technical function6
- Deodorizer4
- Surfactant (surface active agent)2
- Processing aids not otherwise specified2
- Cleaning agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 3 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 8 studies
- Category 6.3A (Category 2)
Skin Irritation · Read Across - Skin Irrit. 2
Skin Irritation · Authoritative - Classification not possible
Skin Sensitization · Screening - Sh
Skin Sensitization · Authoritative - Category 2
Skin Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- A successful topical treatment for cutaneous inflammatory diseases:an additional or alternative therapy to topical steroids. · 2019
- Evidence for chemical and cellular reactivities of the formaldehyde releaser bronopol, independent of formaldehyde release. · 2011
- Exposure to haptens/contact allergens in baby cosmetic products · 2008
- Allergic contact dermatitis from 2‐bromo‐2‐nitropropane‐1,3‐diol in Metrogel® · 2002
- A method for quantification of formaldehyde in the presence of formaldehyde donors in skin‐care products · 1998
Linked databases 27
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU allowed preservatives (Annex V)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- Health Canada Cosmetic Ingredient Hotlist
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubChem
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2 3 4 5
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4 5
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese