Definition
US FDA substance register · UNII 25GT92NY0C · registered name 2-HYDROXYETHYL ACRYLATE · single chemical substance
2-Hydroxyethyl Acrylate is the organic compound that conforms to the formula:
Cosmetic roles
Safety & regulatory references
Korea’s toxic-substance GHS classification: Danger · H412 (category 3) · H302 (category 4) · H310 (category 2) · +4 more
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アクリル酸２－ヒドロキシエチル: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 818-61-1
- EC No.EU chemical inventory number
- 212-454-9
- EC No.EU chemical inventory number
- 212-454-9 (I)
- DTXSIDUS EPA chemical ID
- DTXSID2022123
- DTXCIDUS EPA compound ID
- DTXCID202123
- IUPAC
- 2-Hydroxyethyl prop-2-enoate
- Molecular formula
- C5H8O3
- Molecular weight
- 116.116 g/mol
Measured properties
- Appearance
- Hydroxyethylacrylate appears as a clear colorless liquid. Less dense than water. Vapors heavier than air. Corrosive to tissue. May polymerize exothermically if heated or contaminated. If the polymerization takes place inside a container, the container may rupture violently. Used to make plastics. · Liquid, CBI
- Odour
- Sweet pleasant odor
- Boiling point
- greater than 346 °F at 760 mmHg (USCG, 1999) · 191 °C
- Melting point
- -76 °F (USCG, 1999) · -60.2 °C
- Solubility
- In water, miscible /1X10+6 mg/L/ at 25 °C · Solubility in water: miscible
- Density
- 1.1 at 77 °F (USCG, 1999) - Denser than water, will sink · 1.011 g/cu cm at 23 °C
- Stability
- Stable under recommended storage conditions. Contains the following stabilizer(s): Mequinol (>=200 - <=650 ppm)
- Viscosity
- 5.2 mm²/s at 15 °C · 11.168 cP (@ 25 ℃)
- Colour
- colourless
- Odour threshold
- 3 ppm
- Melting/freezing point
- -60.2 ℃
- Initial boiling point and range
- 210 ℃
- Flash point
- 101 ℃(c.c.)
- Flammability (solid, gas)
- combustible
- Upper/lower flammability or explosive limits
- - / 1.8 % (@ 100 ℃)
- Vapour pressure
- 0.0523 ㎜Hg (@ 25 ℃)
- Water solubility
- 1000000 ㎎/ℓ (@ 25 ℃)
- Vapour density
- 4 (&, gt, 1)
- Relative density
- 1.011 (@ 23 ℃)
- n-Octanol/water partition coefficient (Kow)
- -0.21
- Auto-ignition temperature
- 370 ℃
- Molecular weight
- 116.12
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 11 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Monomers3
- Photosensitive agent2
- Processing aids not otherwise specified2
- Intermediate1
- Film former1
- Binder1
- Dispersing agent1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
7 skin studies and 2 eye studies are on record.
The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Skin Corr. 1B
Skin Irritation · Authoritative - Category 1
Skin Sensitization · Screening - Category 2
Skin Irritation · Screening - Category 6.5B (Category 1)
Skin Sensitization · Read Across - Sh
Skin Sensitization · Authoritative - Skin Sens. 1
Skin Sensitization · Authoritative - Category 8.2C (Category 1C)
Skin Irritation · Read Across - Category 8.3A (Category 1)
Eye Irritation · Read Across - Category 1
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Occupational contact dermatitis in a manicurist · 2019
- Patch Testing in Individuals With Diabetes Using Medical Devices. Part 2-Contact Allergy to Medical Device Allergens and New Patch Test Recommendations. · 2026
- Synthesis and physicochemical properties of pH-sensitive hydrogel based on carboxymethyl chitosan/2-hydroxyethyl acrylate for transdermal delivery of nobiletin · 2019
- Allergic contact dermatitis caused by 2‐hydroxyethyl acrylate in a moisturizing face pack in a handmade acrylic accessory enthusiast · 2018
- Porous dressings of modified chitosan with poly(2-hydroxyethyl acrylate) for topical wound delivery of levofloxacin. · 2016
Linked databases 18
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese