Ingredient Dictionary

2-METHYLPROPANOL

Isobutanol is an alkyl alcohol that is propan-1-ol substituted by a methyl group at position 2.

Definition

Isobutanol is an alkyl alcohol that is propan-1-ol substituted by a methyl group at position 2. It has a role as a Saccharomyces cerevisiae metabolite. It is a primary alcohol and an alkyl alcohol. It derives from a hydride of an isobutane.

Source: PubChem

US FDA substance register · UNII 56F9Z98TEM · registered name ISOBUTYL ALCOHOL · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

2-METHYLPROPANOLINCI1-Propanol, 2-methyl-Synonym

CAS No.chemical registry number: 78-83-1
EC No.EU chemical inventory number: 201-148-0
DTXSIDUS EPA chemical ID: DTXSID0021759
DTXCIDUS EPA compound ID: DTXCID601759

IUPAC: 2-Methylpropan-1-ol
Molecular formula: C4H10O
Molecular weight: 74.123 g/mol

Measured properties

Appearance: Isobutanol appears as a clear colorless liquid with a sweet odor. Flash point 85 - 100 °F. Less dense than water. Vapors heavier than air. · CBI, Liquid
Odour: Sweet, musty odor · Odor like that of amyl alcohol, but weaker
Boiling point: 225 °F at 760 mmHg (NTP, 1992) · 108 °C
Melting point: -162 °F (NTP, 1992) · -108 °C
Solubility: 50 to 100 mg/mL at 61 °F (NTP, 1992) · In water, 66.5-90.9 g/L at 25 °C
Colour: colourless
Melting/freezing point: -108 ℃
Initial boiling point and range: 108 ℃
Flash point: 28 ℃(c.c.)
Upper/lower flammability or explosive limits: 10.9 / 1.7 %
Vapour pressure: 1.2 ㎪(20℃)
Water solubility: 8.7 g/100㎖(20℃)
Relative density: 0.8
n-Octanol/water partition coefficient (Kow): 0.8
Auto-ignition temperature: 415 ℃
Viscosity: 4 cP(15℃)
Molecular weight: 74.12

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 45 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Solvent15
No specific technical function7
Fuel4
Fragrance3
Flavouring and nutrient2
Intermediate2
Processing aids not otherwise specified2
Fuel agents2

8 other uses

Surfactant (surface active agent)1
Plasticizer1
Corrosion inhibitor1
Monomers1
Adhesion/cohesion promoter1
Wetting agent (non-aqueous)1
Conductive agent1
Sealant (barrier)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

11 skin studies and 10 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 21 studies

Category 6.3B (Category 3)
Skin Irritation · Read Across
Skin corrosion/irritation - Category 2
Skin Irritation · Screening
Moderate or Mild Irritation
skin irritation: in vivo · Screening · EPA OTS 798.4470 (Acute Dermal Irritation) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Federal Register 38, No. 187, s 1500.41, p. 27019 according to
Skin Irrit. 2
Skin Irritation · Authoritative
Corrosive
skin irritation: in vivo · Screening · other guideline: Title 49 - Transportation Chapter 1 - Hazardous Materials Regulations Board Department of Transportation Amended s1500,41 to provide a quantitative definition for corrosive materials by utilization of a 4-hr exposure time and nonabraded skin, in the rabb according to
Severe Irritation
skin irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.41 according to
Skin Irrit. 2
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Category 2
Skin Irritation · Screening
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Federal register 38, No. 187, s 1500.42, p. 27019 according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.42 according to
Serious eye damage/eye irritation - Category 2A
Eye Irritation · Screening
Eye Dam. 1
Eye Irritation · Authoritative
Eye Dam. 1
Eye Irritation · Screening
Severe Irritation
eye irritation: in vivo · Screening · EPA OTS 798.4500 (Acute Eye Irritation) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 1
Eye Irritation · Screening