Isobutanol is an alkyl alcohol that is propan-1-ol substituted by a methyl group at position 2.
定義
Isobutanol is an alkyl alcohol that is propan-1-ol substituted by a methyl group at position 2. It has a role as a Saccharomyces cerevisiae metabolite. It is a primary alcohol and an alkyl alcohol. It derives from a hydride of an isobutane.
出典: PubChem
米国FDA 物質登録 · UNII 56F9Z98TEM · 登録名 ISOBUTYL ALCOHOL · 単一の化学物質
化粧品での役割
製品に香りをつけるPERFUMING
安全性・規制情報
韓国の有害物質GHS分類なし · 既存化学物質
詳しい資料 — 表示名・識別番号・物性・試験記録・文献
別名・識別情報
2-METHYLPROPANOLINCI1-Propanol, 2-methyl-別名
- CAS No.化学物質登録番号
- 78-83-1
- EC No.EU化学物質目録番号
- 201-148-0
- DTXSID米国EPA化学物質番号
- DTXSID0021759
- DTXCID米国EPA化合物番号
- DTXCID601759
- IUPAC
- 2-Methylpropan-1-ol
- 分子式
- C4H10O
- 分子量
- 74.123 g/mol
測定された物性
- 性状
- Isobutanol appears as a clear colorless liquid with a sweet odor. Flash point 85 - 100 °F. Less dense than water. Vapors heavier than air. · CBI, Liquid
- 臭い
- Sweet, musty odor · Odor like that of amyl alcohol, but weaker
- 沸点
- 225 °F at 760 mmHg (NTP, 1992) · 108 °C
- 融点
- -162 °F (NTP, 1992) · -108 °C
- 溶解性
- 50 to 100 mg/mL at 61 °F (NTP, 1992) · In water, 66.5-90.9 g/L at 25 °C
- 色
- 無色
- 融点・凝固点
- -108 ℃
- 初留点および沸点範囲
- 108 ℃
- 引火点
- 28 ℃(c.c.)
- 燃焼・爆発範囲の上限/下限
- 10.9 / 1.7 %
- 蒸気圧
- 1.2 ㎪(20℃)
- 溶解度
- 8.7 g/100㎖(20℃)
- 比重
- 0.8
- n-オクタノール/水分配係数（Kow）
- 0.8
- 自然発火温度
- 415 ℃
- 粘度
- 4 cP(15℃)
- 分子量
- 74.12
物質そのものを測定した値です。安全保健公団（KOSHA）の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。
出典: PubChem · 韓国安全保健公団 SDS
製品が実際に使っている用途
米国EPAにこの成分を届け出た製品45件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。
- Solvent15
- No specific technical function7
- Fuel4
- Fragrance3
- Flavouring and nutrient2
- Intermediate2
- Processing aids not otherwise specified2
- Fuel agents2
その他の用途 8件
- Surfactant (surface active agent)1
- Plasticizer1
- Corrosion inhibitor1
- Monomers1
- Adhesion/cohesion promoter1
- Wetting agent (non-aqueous)1
- Conductive agent1
- Sealant (barrier)1
出典: 米国EPA CompTox
刺激・感作試験の記録
皮膚試験11件・眼試験10件の記録があります。
中程度と分類1件
試験の結論はおおむね一致しています（100%）。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。
試験21件をすべて見る
- Category 6.3B (Category 3)
Skin Irritation · Read Across - Skin corrosion/irritation - Category 2
Skin Irritation · Screening - Moderate or Mild Irritation
skin irritation: in vivo · Screening · EPA OTS 798.4470 (Acute Dermal Irritation) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Federal Register 38, No. 187, s 1500.41, p. 27019 according to - Skin Irrit. 2
Skin Irritation · Authoritative - Corrosive
skin irritation: in vivo · Screening · other guideline: Title 49 - Transportation Chapter 1 - Hazardous Materials Regulations Board Department of Transportation Amended s1500,41 to provide a quantitative definition for corrosive materials by utilization of a 4-hr exposure time and nonabraded skin, in the rabb according to - Severe Irritation
skin irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.41 according to - Skin Irrit. 2
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 2
Skin Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Federal register 38, No. 187, s 1500.42, p. 27019 according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.42 according to - Serious eye damage/eye irritation - Category 2A
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Eye Dam. 1
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · EPA OTS 798.4500 (Acute Eye Irritation) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 1
Eye Irritation · Screening
出典: 米国EPA CompTox
関連文献
- Distinguishing between maternally-mediated and directly embryotoxic modes-of-action for postimplantation loss induced in rats by 2-amino-2-methylpropanol. · 2014 · Reproductive toxicology (Elmsford, N.Y.)
- Substrate specificity of human cutaneous alcohol dehydrogenase and erythema provoked by lower aliphatic alcohols. · 1987 · The Journal of investigative dermatology