Isobutanol is an alkyl alcohol that is propan-1-ol substituted by a methyl group at position 2.
定义
Isobutanol is an alkyl alcohol that is propan-1-ol substituted by a methyl group at position 2. It has a role as a Saccharomyces cerevisiae metabolite. It is a primary alcohol and an alkyl alcohol. It derives from a hydride of an isobutane.
来源: PubChem
美国FDA 物质登记 · UNII 56F9Z98TEM · 登记名称 ISOBUTYL ALCOHOL · 单一化学物质
化妆品中的作用
为产品增添香味PERFUMING
安全与法规参考
未列入韩国有毒物质 GHS 分类 · 现有化学物质
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
2-METHYLPROPANOLINCI1-Propanol, 2-methyl-同义名
- CAS No.化学物质登记号
- 78-83-1
- EC No.欧盟化学品目录编号
- 201-148-0
- DTXSID美国EPA化学品编号
- DTXSID0021759
- DTXCID美国EPA化合物编号
- DTXCID601759
- IUPAC
- 2-Methylpropan-1-ol
- 分子式
- C4H10O
- 分子量
- 74.123 g/mol
实测物性
- 性状
- Isobutanol appears as a clear colorless liquid with a sweet odor. Flash point 85 - 100 °F. Less dense than water. Vapors heavier than air. · CBI, Liquid
- 气味
- Sweet, musty odor · Odor like that of amyl alcohol, but weaker
- 沸点
- 225 °F at 760 mmHg (NTP, 1992) · 108 °C
- 熔点
- -162 °F (NTP, 1992) · -108 °C
- 溶解性
- 50 to 100 mg/mL at 61 °F (NTP, 1992) · In water, 66.5-90.9 g/L at 25 °C
- 颜色
- 无色
- 熔点/凝固点
- -108 ℃
- 初沸点和沸程
- 108 ℃
- 闪点
- 28 ℃(c.c.)
- 燃烧或爆炸范围上限/下限
- 10.9 / 1.7 %
- 蒸气压
- 1.2 ㎪(20℃)
- 溶解度
- 8.7 g/100㎖(20℃)
- 比重
- 0.8
- 正辛醇/水分配系数（Kow）
- 0.8
- 自燃温度
- 415 ℃
- 黏度
- 4 cP(15℃)
- 分子量
- 74.12
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
这是向美国 EPA 申报含该成分的 45 款产品的用途。其中包括化妆品以外的产品，排在前几行的即为该成分的主要用途。
- Solvent15
- No specific technical function7
- Fuel4
- Fragrance3
- Flavouring and nutrient2
- Intermediate2
- Processing aids not otherwise specified2
- Fuel agents2
其余用途 8 项
- Surfactant (surface active agent)1
- Plasticizer1
- Corrosion inhibitor1
- Monomers1
- Adhesion/cohesion promoter1
- Wetting agent (non-aqueous)1
- Conductive agent1
- Sealant (barrier)1
来源: 美国EPA CompTox
刺激与致敏试验记录
记录有皮肤试验 11 项、眼部试验 10 项。
归类为中等1 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 21 项试验
- Category 6.3B (Category 3)
Skin Irritation · Read Across - Skin corrosion/irritation - Category 2
Skin Irritation · Screening - Moderate or Mild Irritation
skin irritation: in vivo · Screening · EPA OTS 798.4470 (Acute Dermal Irritation) according to OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: Federal Register 38, No. 187, s 1500.41, p. 27019 according to - Skin Irrit. 2
Skin Irritation · Authoritative - Corrosive
skin irritation: in vivo · Screening · other guideline: Title 49 - Transportation Chapter 1 - Hazardous Materials Regulations Board Department of Transportation Amended s1500,41 to provide a quantitative definition for corrosive materials by utilization of a 4-hr exposure time and nonabraded skin, in the rabb according to - Severe Irritation
skin irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.41 according to - Skin Irrit. 2
Skin Irritation · Screening - Classification not possible
Skin Sensitization · Screening - Category 2
Skin Irritation · Screening - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Federal register 38, No. 187, s 1500.42, p. 27019 according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · other guideline: Code of Federal Regulations, Title 16, Section 1500.42 according to - Serious eye damage/eye irritation - Category 2A
Eye Irritation · Screening - Eye Dam. 1
Eye Irritation · Authoritative - Eye Dam. 1
Eye Irritation · Screening - Severe Irritation
eye irritation: in vivo · Screening · EPA OTS 798.4500 (Acute Eye Irritation) according to OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 1
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- Distinguishing between maternally-mediated and directly embryotoxic modes-of-action for postimplantation loss induced in rats by 2-amino-2-methylpropanol. · 2014 · Reproductive toxicology (Elmsford, N.Y.)
- Substrate specificity of human cutaneous alcohol dehydrogenase and erythema provoked by lower aliphatic alcohols. · 1987 · The Journal of investigative dermatology