3-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3.
Definition
3-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. It has been isolated from Taxus baccata. It is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc. It has a role as a plant metabolite and a bacterial metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 3-hydroxybenzoate.
Source: PubChem
US FDA substance register · UNII 2ZFW40OJ7U · registered name 3-Hydroxybenzoic acid · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name ３－ヒドロキシ安息香酸: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 99-06-9
- EC No.EU chemical inventory number
- 202-726-5
- DTXSIDUS EPA chemical ID
- DTXSID6021610
- DTXCIDUS EPA compound ID
- DTXCID601610
- IUPAC
- 3-Hydroxybenzoic acid
- Molecular formula
- C7H6O3
- Molecular weight
- 138.122 g/mol
Measured properties
- Appearance
- White or off-white powder, [Alfa Aesar MSDS] · Solid
- Melting point
- 202 °C
- Solubility
- 7.25 mg/mL at 25 °C · Soluble
- Colour
- white
- Melting/freezing point
- 202 ℃
- Water solubility
- 7.25 ㎎/㎖
- Relative density
- 1.473 (at 4 C)
- n-Octanol/water partition coefficient (Kow)
- 1.5
- Molecular weight
- 138.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Flavouring and nutrient1
- Softener and conditioner1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 2 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
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- Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers · 2023
- Utilization of Melon Skin Waste (Cucumis Melo L.) in Syrup Preparations as an Immunostimulant to Prevent Covid-19 · 2022
- Bacterial Cellulose Membrane Containing Epilobium angustifolium L. Extract as a Promising Material for the Topical Delivery of Antioxidants to the Skin · 2021
Linked databases 19
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
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