Ingredient Dictionary

4,4'-ISOPROPYLIDENEDIPHENOL

Bisphenol A (BPA) can cause developmental toxicity according to The National Toxicology Program's Center for the Evaluation of Risks to Human Reproduction.

Definition

Bisphenol A (BPA) can cause developmental toxicity according to The National Toxicology Program's Center for the Evaluation of Risks to Human Reproduction. It can cause female reproductive toxicity according to an independent committee of scientific and health experts.

Source: PubChem

US FDA substance register · UNII MLT3645I99 · registered name BISPHENOL A · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

4,4'-(1-Methylethylidene)Bisphenol

Cosmetic roles

No declared roleNOT REPORTED

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)

Korea’s toxic-substance GHS classification: Danger · H411 (category 2) · H317 (category 1) · H360 (category 3) · +2 more

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1176

Source: EU prohibited substances (Annex II)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/1176 CMR 1B · Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

4,4'-ISOPROPYLIDENEDIPHENOLINCI4,4’-아이소프로필리덴다이페놀Korean label name (MFDS standard)Phenol, 4,4'-(1-methylethylidene)bis-Synonym

CAS No.chemical registry number: 80-05-7
EC No.EU chemical inventory number: 201-245-8
DTXSIDUS EPA chemical ID: DTXSID7020182
DTXCIDUS EPA compound ID: DTXCID30182

IUPAC: 4,4'-(Propane-2,2-diyl)diphenol
Molecular formula: C15H16O2
Molecular weight: 228.291 g/mol

Measured properties

Colour: white
pH: 6.4
Melting/freezing point: 160 ℃
Initial boiling point and range: 360.5 ℃(760 ㎜Hg)
Flash point: 227 ℃
Vapour pressure: 4.0E-8 ㎜Hg (25℃)
Water solubility: 300 ㎎/ℓ (25℃)
Vapour density: 1.2 g/㎤
Relative density: 1.195 (25/25℃)
n-Octanol/water partition coefficient (Kow): 3.32
Auto-ignition temperature: 510~570 ℃
Molecular weight: 228.287

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 52 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Monomers17
Hardener15
Processing aids not otherwise specified4
Intermediate3
Hydraulic fluids3
Lubricating agent2
Propellants, non-motive (blowing agents)2
Flame retardant2

4 other uses

Antioxidant1
No specific technical function1
Catalyst1
Binder1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

7 skin studies and 5 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 12 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)
Skin sensitisation - category 1
Skin Sensitization · Screening
Skin sensitization - Category 1
Skin Sensitization · Screening
Not classified
Skin Irritation · Screening
Skin Sens. 1
Skin Sensitization · Authoritative
Category 1
Skin Sensitization · Screening
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Eye damage - category 1
Eye Irritation · Screening
Category 1
Eye Irritation · Screening
Serious eye damage/eye irritation - Category 1
Eye Irritation · Screening
Eye Dam. 1
Eye Irritation · Authoritative
Category 8.3A (Category 1)
Eye Irritation · Read Across