- 韩国限量
- 1.0%
产品中实际含有多少
暂无产品标示该成分含量。
含该成分的产品中,0 款将其列在 1% 线之前,4 款列在之后(通常不超过 1%)。
含有此成分的产品
已确认 4 款中的 4 款 · 按含量充足程度排序
定义
美国FDA 物质登记 · UNII UBB8XEB10B · 登记名称 4-AMINO-2-HYDROXYTOLUENE · 单一化学物质
化妆品中的作用
安全与法规参考
- 限用
- 韩国 · 英国
来源: 东盟化妆品指令 · 欧盟化妆品法规 · 韩国食药处 化妆品法规信息 · 台湾FDA 化妆品成分 · 台湾FDA 化妆品法规 · 英国化妆品法规
东盟
- Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 % The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows
台湾
- ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
- ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
- ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
- ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
- 用途 : 使用限制
- 最大配合量 : 氧化性染髮產品 : 1.5%
中国
- 最大配合量 : 1.5%
欧盟
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Products intented for colouring eyelashes
- Other : For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 1,5 % (b) For professional use only.
- Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions.Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.†(b) To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer:— has a rash on the face or sensitive, irritated and damaged scalp,— has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them.â€
来源: 韩国食药处 化妆品法规信息
欧盟化妆品法规 附录III(限用物质) 第241项 · 适用 (a) Hair dye substance in oxidative hair dye products (b) Products intented for colouring eyelashes
来源: 欧盟限用成分(附录III)
Restriction III/241 · Other restriction: ban substances that deplete the ozone layer
来源: 欧盟 CosIng 成分清单
Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2005/2006
来源: 美国CIR 安全性评估
Reviewed by CIR: Final Report on the Safety Assessment of 4-Amino-2-Hydroxytoluene
来源: 美国CIR 安全性评估
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
- CAS No.化学物质登记号
- 2835-95-2
- EC No.欧盟化学品目录编号
- 220-618-6
- DTXSID美国EPA化学品编号
- DTXSID9024489
- DTXCID美国EPA化合物编号
- DTXCID204489
- IUPAC
- 5-Amino-2-methylphenol
- 分子式
- C7H9NO
- 分子量
- 123.155 g/mol
实测物性
- 性状
- 固体
- 颜色
- 无色
- 熔点/凝固点
- 161 ℃
- 初沸点和沸程
- 259 ℃
- 闪点
- 116.3 ℃
- 蒸气压
- 0.00308 ㎜Hg
- 溶解度
- 2427 ㎎/ℓ
- 正辛醇/水分配系数(Kow)
- 0.79
- 分子量
- 123.15
这是对物质本身测得的数值。韩国安全保健公团(KOSHA)的资料仅供编写和审核安全数据表参考,并非原料商品的规格。
来源: 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 3 项、眼部试验 1 项。
试验结论基本一致(100%)。 这是对原料本身的试验记录,与成品中所含浓度下的刺激性不同。
查看全部 4 项试验
- SkinSens1
Skin Sensitization · QSAR Predicted - Classification not possible
Skin Irritation · Screening - Category 1
Skin Sensitization · Screening - Category 2B
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first‐pass skin metabolism of the hair dye, 4‐amino‐2‐hydroxytoluene · 2023
- P05-02 Use of a dynamic skin and liver co-culture model to investigate the effect of application route on the metabolism of the hair dye, 4-amino-2-hydroxytoluene · 2022
- Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model · 2021
- N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential. · 2014
- Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo. · 2009
关联数据库 23
- 澳大利亚工业化学品名录(AICIS)
- 东盟化妆品指令
- 韩国安全保健公团 安全数据表
- 韩国化妆品协会成分词典
- 韩国食药处 化妆品法规信息 2 3 4
- 韩国食药处 化妆品原料成分 2
- 美国CIR 安全性评估 2 3
- 美国EPA 化学品数据库(DSSTox)
- 美国EPA CompTox 2
- 美国FDA 物质登记(GSRS)
- 美国FDA 物质识别码(UNII)
- 欧盟 CosIng 成分清单 2
- 欧盟 SCCS 安全意见
- 欧盟化妆品法规
- 欧盟限用成分(附录III)
- 台湾FDA 化妆品成分
- 台湾FDA 化妆品法规
- 英国化妆品法规
- 中国已使用化妆品原料目录(IECIC)
- ChEMBL
- Tlooto 学术文献检索 2 3 4 5
- UniChem 化学物质统一 ID
- Wikidata