4-Amino-2-nitrophenol can cause cancer according to an independent committee of scientific and health experts.
Definition
4-Amino-2-nitrophenol can cause cancer according to an independent committee of scientific and health experts.
Source: PubChem
US FDA substance register · UNII N3499RCQ6B · registered name 4-AMINO-2-NITROPHENOL · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
EU Cosmetics Regulation, Annex II (prohibited substances), entry 412
Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics
Restriction II/412
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
CIR reviewed this ingredient and flagged its status as: CIR insufficient data ingredients - use not supported (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 119-34-6
- DTXSIDUS EPA chemical ID
- DTXSID6020064
- DTXCIDUS EPA compound ID
- DTXCID4064
- IUPAC
- 4-Amino-2-nitrophenol
- Molecular formula
- C6H6N2O3
- Molecular weight
- 154.125 g/mol
Measured properties
- Appearance
- 4-amino-2-nitrophenol appears as dark red plates, needles or reddish-purple powder. Melting point 125-127 °C. · Dark red solid, [HSDB] Red-brown crystalline powder, [MSDSonline]
- Boiling point
- 110 °C at 12 mm Hg
- Melting point
- 261 °F (NTP, 1992) · 131 °C
- Solubility
- less than 0.1 mg/mL at 70 °F (NTP, 1992) · Soluble in water, ethanol, diethyl ether, slightly soluble in dimethylsulfoxide
- Dissociation constant
- pKa = 7.81 at 25 °C (phenol)
- Melting/freezing point
- 131 ℃()
- Initial boiling point and range
- 110 ℃
- Vapour pressure
- 0.000035 ㎜Hg (25C)
- Water solubility
- 11000 ㎎/ℓ (25C)
- n-Octanol/water partition coefficient (Kow)
- 0.96
- Molecular weight
- 154.13
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
1 skin studies and 0 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 1 studies
- SkinSens1
Skin Sensitization · QSAR Predicted
Source: US EPA CompTox dashboard
Related literature
Linked databases 23
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- Health Canada Cosmetic Ingredient Hotlist
- IARC carcinogen classification
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- US National Toxicology Program reports
- Wikidata