Definición
Registro de sustancias de la FDA (EE. UU.) · UNII R5WY41Q95Z · nombre registrado 4-AMINO-3-NITROPHENOL · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Prohibido
- Corea del Sur
- Restringido
- Reino Unido · Taiwán
Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)
ASEAN
- Field of application and/or use : (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Maximum authorised concentration in the finished cosmetic product : (b) 1.0%
- Other limitations and requirements : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% The direction for use “wear suitable gloves” must be included in label or leaflet text
- Conditions of use and warning which must be printed on the labels : (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past (b) Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows
China
- Concentración máxima : 1.5%
- Concentración máxima : 1%
Unión Europea
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b)Hair dye substance in non-oxidative hair dye products
- Maximum concentration in ready for use preparation : (b) 1.0%
- Other : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,5 %
- Wording of conditions of use and warnings : (a) and (b) “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp,EN L 114/40 OJ EU25.4.2013 — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ...
Fuente: Información regulatoria cosmética del MFDS (Corea)
Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 215 · concentración máxima (b) 1.0% · se aplica a (a) Hair dye substance in oxidative hair dye products (b)Hair dye substance in non-oxidative hair dye products
Restriction III/215 · Other restriction: ban substances that deplete the ozone layer
Reviewed by CIR: Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres y definiciones oficiales
Nombre de etiquetado de la JCIA 4-アミノ-3-ニトロフェノール: 本品は、次の化学式で表される芳香族アミンである。
Nombres e identificadores
- CAS No.número de registro químico
- 610-81-1
- EC No.número de inventario químico de la UE
- 210-236-8
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID50209864
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID00132355
- IUPAC
- 4-Amino-3-nitrophenol
- Fórmula molecular
- C6H6N2O3
- Peso molecular
- 154.125 g/mol
Para qué lo usan los productos
Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Dye3
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 3 estudios en piel y 1 en ojos.
Las conclusiones de los estudios coinciden en general (100%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 4 estudios
- SkinIrr2
Skin Irritation · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) Adopted : 24th April 2002 - Ambiguous
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 12 May 1981 according to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Analytical Method Development and Dermal Absorption of 4-Amino-3-Nitrophenol (4A3NP), a Hair Dye Ingredient under the Oxidative or Non-Oxidative Condition · 2024
- Comparison of the metabolism of 10 cosmetics‐relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants · 2019
- Comparison of the metabolism of 10 chemicals in human and pig skin explants · 2018
- Allergy to 3‐nitro‐p‐hydroxyethylaminophenol and 4‐amino‐3‐nitrophenol in a hair dye · 2005
- Allergy to 4‐amino‐3‐nitrophenol in a hair dye · 1998
Bases de datos vinculadas 22
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3 4 5
- Cosmetic Ingredient Review (CIR, EE. UU.) 2
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Dictámenes de seguridad del SCCS (UE) 2 3
- Directiva cosmética de la ASEAN
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Ingredientes cosméticos de la FDA de Taiwán
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- NIST Chemistry WebBook
- Nombres de etiquetado de la JCIA (Japón)
- Normativa cosmética de la FDA de Taiwán
- Normativa cosmética del Reino Unido (OPSS)
- Panel CompTox de la EPA 2
- Registro de sustancias de la FDA (GSRS)
- Reglamento de cosméticos de la UE
- Sustancias restringidas UE (anexo III)
- Wikidata