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Ingredientes

Diccionario de ingredientes

4-AMINO-M-CRESOL

4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.

Estructura molecular

Definición

4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine. It has a role as a drug metabolite. It is a member of phenols and a substituted aniline.

Fuente: PubChem

Registro de sustancias de la FDA (EE. UU.) · UNII 12R07I1K8C · nombre registrado 4-AMINO-M-CRESOL · sustancia química única

Fuente: Identificador único de ingredientes de la FDA (UNII)

Funciones cosméticas

Tiñe el cabelloHAIR DYEING

Referencias de seguridad y regulación

Prohibido
Corea del Sur
Restringido o prohibido
Corea del Sur · Taiwán
Restringido
Reino Unido · Taiwán

Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)

ASEAN

  • Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
  • Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 % The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

China

  • Concentración máxima : 1.5%

Unión Europea

  • Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes
  • Other : For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 1,5 % b) For professional use only.
  • Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.” (b) To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp,— has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them.”

Fuente: Información regulatoria cosmética del MFDS (Corea)

Sin clasificación en la lista GHS de sustancias tóxicas de Corea · sustancia química existente

Fuente: Registro GHS de sustancias tóxicas de Corea (NIER)

Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 244 · se aplica a (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes

Fuente: Sustancias restringidas UE (anexo III)

Restriction III/244

Fuente: Lista de ingredientes CosIng (UE)

Reviewed by CIR: Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Reviewed by CIR: Final Report: Amended Safety Assessment of 4-Amino-m-Cresol as Used in Cosmetics

Fuente: Cosmetic Ingredient Review (CIR, EE. UU.)

Más datos: nombres, identificadores, propiedades, ensayos y literatura

Nombres e identificadores

4-AMINO-M-CRESOLINCI4-아미노-m-크레솔Nombre en etiquetas coreanas (estándar MFDS)Phenol, 4-amino-3-methyl-Sinónimo
CAS No.número de registro químico
2835-99-6
EC No.número de inventario químico de la UE
220-621-2
DTXSIDidentificador químico de la EPA (EE. UU.)
DTXSID2049262
DTXCIDidentificador de compuesto de la EPA (EE. UU.)
DTXCID7029118
IUPAC
4-Amino-3-methylphenol
Fórmula molecular
C7H9NO
Peso molecular
123.155 g/mol

Propiedades medidas

Aspecto
sólido
Punto de fusión/congelación
178~180 ℃ (1 atm)
Punto inicial e intervalo de ebullición
156~190 ℃ (1 atm)
Inflamabilidad (sólido, gas)
EU Method A.10, GLP
Presión de vapor
&amp, lt, 0.003 ㎩ (40 °C)
Solubilidad en agua
1400 ㎎/ℓ (25 °C, pH: 7.6)
Densidad relativa
1.243 g/mL
Coeficiente de reparto n-octanol/agua (Kow)
0.49
Peso molecular
123.1541

Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.

Fuente: Fichas de datos de seguridad de KOSHA (Corea)

Para qué lo usan los productos

Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.

  • Dye3

Fuente: Panel CompTox de la EPA

Estudios de irritación y sensibilización

Constan 3 estudios en piel y 2 en ojos.

Clasificado como muy irritante1

Las conclusiones de los estudios coinciden en general (100%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.

Ver los 5 estudios
  • SkinIrr2
    Skin Irritation · QSAR Predicted
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • Studies Indicate No Significant Irritation
    eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to
  • Moderate or Mild Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to

Fuente: Panel CompTox de la EPA

Literatura relacionada

Bases de datos vinculadas 27