4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.
Definición
4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine. It has a role as a drug metabolite. It is a member of phenols and a substituted aniline.
Fuente: PubChem
Registro de sustancias de la FDA (EE. UU.) · UNII 12R07I1K8C · nombre registrado 4-AMINO-M-CRESOL · sustancia química única
Fuente: Identificador único de ingredientes de la FDA (UNII)
Funciones cosméticas
Referencias de seguridad y regulación
- Prohibido
- Corea del Sur
- Restringido o prohibido
- Corea del Sur · Taiwán
- Restringido
- Reino Unido · Taiwán
Fuente: Información regulatoria cosmética del MFDS (Corea) · Directiva cosmética de la ASEAN · Reglamento de cosméticos de la UE · Ingredientes cosméticos de la FDA de Taiwán · Normativa cosmética de la FDA de Taiwán · Normativa cosmética del Reino Unido (OPSS)
ASEAN
- Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 % The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows
China
- Concentración máxima : 1.5%
Unión Europea
- Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes
- Other : For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 1,5 % b) For professional use only.
- Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.†(b) To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp,— has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them.â€
Fuente: Información regulatoria cosmética del MFDS (Corea)
Sin clasificación en la lista GHS de sustancias tóxicas de Corea · sustancia química existente
Reglamento de cosméticos de la UE, anexo III (sustancias restringidas), entrada 244 · se aplica a (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes
Restriction III/244
Reviewed by CIR: Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol
Reviewed by CIR: Final Report: Amended Safety Assessment of 4-Amino-m-Cresol as Used in Cosmetics
Más datos: nombres, identificadores, propiedades, ensayos y literatura
Nombres e identificadores
- CAS No.número de registro químico
- 2835-99-6
- EC No.número de inventario químico de la UE
- 220-621-2
- DTXSIDidentificador químico de la EPA (EE. UU.)
- DTXSID2049262
- DTXCIDidentificador de compuesto de la EPA (EE. UU.)
- DTXCID7029118
- IUPAC
- 4-Amino-3-methylphenol
- Fórmula molecular
- C7H9NO
- Peso molecular
- 123.155 g/mol
Propiedades medidas
- Aspecto
- sólido
- Punto de fusión/congelación
- 178~180 ℃ (1 atm)
- Punto inicial e intervalo de ebullición
- 156~190 ℃ (1 atm)
- Inflamabilidad (sólido, gas)
- EU Method A.10, GLP
- Presión de vapor
- &, lt, 0.003 ㎩ (40 °C)
- Solubilidad en agua
- 1400 ㎎/ℓ (25 °C, pH: 7.6)
- Densidad relativa
- 1.243 g/mL
- Coeficiente de reparto n-octanol/agua (Kow)
- 0.49
- Peso molecular
- 123.1541
Valores medidos en la sustancia en sí. Los datos de KOSHA son una referencia para redactar y revisar fichas de seguridad, no una especificación de una materia prima comercial.
Para qué lo usan los productos
Usos de los 3 productos declarados ante la EPA de EE. UU. con este ingrediente. Incluye productos que no son cosméticos, así que las primeras filas son sus usos principales.
- Dye3
Fuente: Panel CompTox de la EPA
Estudios de irritación y sensibilización
Constan 3 estudios en piel y 2 en ojos.
Las conclusiones de los estudios coinciden en general (100%). Son ensayos de la materia prima en sí; la irritación a la cantidad de un producto terminado es otra cuestión.
Ver los 5 estudios
- SkinIrr2
Skin Irritation · QSAR Predicted - High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - SkinSens1
Skin Sensitization · QSAR Predicted - Studies Indicate No Significant Irritation
eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to - Moderate or Mild Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to
Fuente: Panel CompTox de la EPA
Literatura relacionada
- Measurement Methods for Aromatic Amines in Urine, Shampoo-water Mixture, and River Water using Solid Phase Extraction Liquid Chromatography/tandem Mass Spectrometry · 2015
- Final report on the safety assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol. · 2004
- Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol1 · 2004
Bases de datos vinculadas 27
- Base de datos química DSSTox de la EPA
- Búsqueda bibliográfica Tlooto 2 3
- ChEBI
- ChEMBL
- Cosmetic Ingredient Review (CIR, EE. UU.) 2 3
- Diccionario de ingredientes de la Asociación Coreana de Cosméticos
- Dictámenes de seguridad del SCCS (UE)
- Directiva cosmética de la ASEAN
- Fichas de datos de seguridad de KOSHA (Corea)
- Identificador único de ingredientes de la FDA (UNII)
- Identificadores cruzados UniChem
- Información regulatoria cosmética del MFDS (Corea) 2 3 4
- Ingredientes cosméticos de la FDA de Taiwán
- Inventario de ingredientes de China (IECIC)
- Inventario de productos químicos de Australia (AICIS)
- Lista de ingredientes CosIng (UE) 2
- NIST Chemistry WebBook
- Normativa cosmética de la FDA de Taiwán
- Normativa cosmética del Reino Unido (OPSS)
- Panel CompTox de la EPA 2
- PubChem
- Registro de ingredientes cosméticos del MFDS (Corea) 2
- Registro de sustancias de la FDA (GSRS)
- Registro GHS de sustancias tóxicas de Corea (NIER)
- Reglamento de cosméticos de la UE
- Sustancias restringidas UE (anexo III)
- Wikidata