Gloshell
成分辞典

成分辞典

4-AMINO-M-CRESOL

4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine.

分子構造

定義

4-hydroxy-6-methylaniline is a substituted aniline in which the aniline ring carries 4-hydroxy and 6-methyl substituents; a urinary metabolite of lidocaine. It has a role as a drug metabolite. It is a member of phenols and a substituted aniline.

出典: PubChem

米国FDA 物質登録 · UNII 12R07I1K8C · 登録名 4-AMINO-M-CRESOL · 単一の化学物質

出典: 米国FDA 物質識別番号(UNII)

化粧品での役割

髪を染めるHAIR DYEING

安全性・規制情報

禁止
韓国
制限・禁止
韓国
制限
イギリス

出典: 韓国食薬処 化粧品規制情報 · ASEAN 化粧品指令 · EU 化粧品規則 · 台湾FDA 化粧品成分 · 台湾FDA 化粧品規制 · 英国 化粧品規則

ASEAN

  • Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
  • Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5 % The direction for use “wear suitable gloves” must be included in label or leaflet text.
  • Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

台湾

  • ※ 染髮產品之限量標準:係指該成分依產品使用說明書混合後之最高允許使用量。
  • ※ 化粧品之外包裝或容器,應明顯標示本表所列成分之注意事項。因外包裝或容器表面積過小或其他特殊情形致不能標示者,應於標籤、仿單或以其他方式刊載之。
  • ※ 本表所稱之口腔製劑,包含非藥用牙膏、漱口水類及美白牙齒類等化粧品。
  • ※ 化粧品宣稱效能者,須符合化粧品標示宣傳廣告涉及虛偽誇大或醫療效能認定準則規定。
  • 用途 : 使用限制
  • 最大配合量 : 氧化性染髮產品 : 1.5%

中国

  • 最大配合量 : 1.5%

欧州連合

  • Product Type, body parts : (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes
  • Other : For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair or eyelashes must not exceed 1,5 % b) For professional use only.
  • Wording of conditions of use and warnings : (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.” (b) To be printed on the label: The mixing ratio. “For professional use only. This product can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase the risk of allergy. Eyelashes shall not be coloured if the consumer: — has a rash on the face or sensitive, irritated and damaged scalp,— has experienced any reaction after colouring hair or eyelashes, — has experienced a reaction to a temporary ‘black henna’ tattoo in the past. Rinse eyes immediately if product comes into contact with them.”

出典: 韓国食薬処 化粧品規制情報

韓国の有害物質GHS分類なし · 既存化学物質

出典: 韓国 有害物質GHS情報(環境公団)

EU化粧品規則 附属書III(制限物質) 第244項 · 適用 (a) Hair dye substance in oxidative hair dye products (b) Products intended for colouring eyelashes

出典: EU 制限成分(附属書III)

Restriction III/244

出典: EU CosIng 成分リスト

Reviewed by CIR: Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol

出典: 米国CIR 安全性評価

Reviewed by CIR: Final Report: Amended Safety Assessment of 4-Amino-m-Cresol as Used in Cosmetics

出典: 米国CIR 安全性評価

詳しい資料 — 表示名・識別番号・物性・試験記録・文献

別名・識別情報

4-AMINO-M-CRESOLINCI4-아미노-m-크레솔韓国の表示名(食薬処標準名)Phenol, 4-amino-3-methyl-別名
CAS No.化学物質登録番号
2835-99-6
EC No.EU化学物質目録番号
220-621-2
DTXSID米国EPA化学物質番号
DTXSID2049262
DTXCID米国EPA化合物番号
DTXCID7029118
IUPAC
4-Amino-3-methylphenol
分子式
C7H9NO
分子量
123.155 g/mol

測定された物性

性状
固体
融点・凝固点
178~180 ℃ (1 atm)
初留点および沸点範囲
156~190 ℃ (1 atm)
可燃性(固体、気体)
EU Method A.10, GLP
蒸気圧
&amp, lt, 0.003 ㎩ (40 °C)
溶解度
1400 ㎎/ℓ (25 °C, pH: 7.6)
比重
1.243 g/mL
n-オクタノール/水分配係数(Kow)
0.49
分子量
123.1541

物質そのものを測定した値です。安全保健公団(KOSHA)の資料はSDS作成・確認の参考用で、原料商品の規格ではありません。

出典: 韓国安全保健公団 SDS

製品が実際に使っている用途

米国EPAにこの成分を届け出た製品3件の用途です。化粧品以外の製品も含まれるため、上の数行がこの成分の主な使い道といえます。

  • Dye3

出典: 米国EPA CompTox

刺激・感作試験の記録

皮膚試験3件・眼試験2件の記録があります。

刺激が強いと分類1件

試験の結論はおおむね一致しています(100%)。 原料そのものを試験した記録で、完成品に含まれる濃度での刺激性とは異なります。

試験5件をすべて見る
  • SkinIrr2
    Skin Irritation · QSAR Predicted
  • High Frequency of Sensitization
    skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
  • SkinSens1
    Skin Sensitization · QSAR Predicted
  • Studies Indicate No Significant Irritation
    eye irritation: in vitro / ex vivo · Screening · other guideline: OECD Guideline 438 (Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage) Adopted : 26 July 2013 according to
  • Moderate or Mild Irritation
    eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to

出典: 米国EPA CompTox

関連文献

連携データベース 27