2-Amino-4-Chlorophenol can cause cancer according to California Labor Code.
Definition
2-Amino-4-Chlorophenol can cause cancer according to California Labor Code.
Source: PubChem
US FDA substance register · UNII 2Z43LEA3DX · registered name 4-Chloro-2-aminophenol · single chemical substance
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 1219
Restriction II/1219
Source: EU CosIng ingredient list
Reviewed by CIR: Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol
Reviewed by CIR: Final Report: Amended Safety Assessment of 4-Chloro-2-Aminophenol as Used in Cosmetics
CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 95-85-2
- EC No.EU chemical inventory number
- 202-458-9
- DTXSIDUS EPA chemical ID
- DTXSID5024473
- DTXCIDUS EPA compound ID
- DTXCID504473
- IUPAC
- 2-Amino-4-chlorophenol
- Molecular formula
- C6H6ClNO
- Molecular weight
- 143.57 g/mol
Measured properties
- Appearance
- 2-Amino-4-chlorophenol is a light brown colored crystalline solid. It may be toxic by ingestion. It is insoluble in water. It is used to make other chemicals. · Brown solid, [ICSC] Brown powder, [Alfa Aesar MSDS]
- Melting point
- 284 to 286 °F (decomposes) (NTP, 1992) · 140 °C
- Solubility
- less than 1 mg/mL at 68 °F (NTP, 1992) · Solubility in water, g/l at 26 °C: 3 (slightly soluble)
- Melting/freezing point
- 140 ℃
- Vapour pressure
- 0.00141 ㎜Hg
- Water solubility
- 2300 ㎎/ℓ
- n-Octanol/water partition coefficient (Kow)
- 1.81
- Molecular weight
- 143.6
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
3 skin studies and 1 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- SkinSens1
Skin Sensitization · QSAR Predicted - Classification not possible
Skin Sensitization · Screening - Classification not possible
Skin Irritation · Screening - Classification not possible
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
- Final report on the safety assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol. · 2004
- Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol, and 4-Chloro-2-Aminophenol1 · 2004
Linked databases 22
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- IARC carcinogen classification
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Taiwan FDA cosmetic ingredients
- Tlooto literature search 2
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3 4
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata