Definition
US FDA substance register · UNII 87045U29QJ · registered name 4-CHLORORESORCINOL · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- Taiwan · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)
ASEAN
- Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
- Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.5% The direction for use “wear suitable gloves” must be included in label or leaflet text.
- Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows
China
- Maximum concentration : 0.5%
European Union
- Product Type, body parts : Hair dye substance in oxidative hair dye products
- Other : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.5%
- Wording of conditions of use and warnings : To be printed on the label: Hair colorants can cause severe allergic reactions.
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex III (restricted substances), entry 199 · applies to Hair dye substance in oxidative hair dye products
Restriction Annex III/199 · SCCS opinion: Opinion on 4-Chlororesorcinol
Source: EU CosIng ingredient list
Reviewed by CIR: 40th Anniversary Overview and Rereview Summaries From 2011 to 2015
Reviewed by CIR: Final Report on the Safety Assessment of 4-Chlororesorcinol
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name クロロレゾルシノール: 本品は、レゾルシン（＊）の塩化物であり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 95-88-5
- EC No.EU chemical inventory number
- 202-462-0
- DTXSIDUS EPA chemical ID
- DTXSID8052643
- DTXCIDUS EPA compound ID
- DTXCID5031216
- IUPAC
- 4-Chlorobenzene-1,3-diol
- Molecular formula
- C6H5ClO2
- Molecular weight
- 144.55 g/mol
Measured properties
- Appearance
- solid
- Melting/freezing point
- 107 ℃
- Vapour pressure
- 0.00120 (NLM)
- Water solubility
- 8840 (NLM)
- Molecular weight
- 144.55
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye3
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
6 skin studies and 2 eye studies are on record.
The study conclusions largely agree (67%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 8 studies
- High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation) - SkinIrr2
Skin Irritation · QSAR Predicted - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · other guideline: according to - Category 6.3A (Category 2)
Skin Irritation · Read Across - SkinSens1
Skin Sensitization · QSAR Predicted - Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EPA OPPTS 870.2500 (Acute Dermal Irritation) according to - Severe Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EPA OPPTS 870.2400 (Acute Eye Irritation) according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across
Source: US EPA CompTox dashboard
Related literature
Linked databases 25
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU restricted substances (Annex III)
- EU SCCS safety opinions
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3 4
- NIST Chemistry WebBook
- PubMed
- Taiwan FDA cosmetic ingredients
- Taiwan FDA cosmetic regulations
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2 3
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata