Ingredient Dictionary

4-NITRO-M-PHENYLENEDIAMINE

4-nitro-1,3-phenylenediamine is a C-nitro compound.

Definition

4-nitro-1,3-phenylenediamine is a C-nitro compound.

Source: PubChem

US FDA substance register · UNII 0D5U5EW62Z · registered name 4-NITRO-M-PHENYLENEDIAMINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Dyes hairHAIR DYEING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · China · European Union · South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex II (prohibited substances), entry 1282

Source: EU prohibited substances (Annex II)

Restriction II/1282

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of 4-Nitro-m-Phenylenediamine

Source: US Cosmetic Ingredient Review (CIR)

CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

4-NITRO-M-PHENYLENEDIAMINEINCI1,3-Benzenediamine, 4-nitro-Synonym4-나이트로-m-페닐렌다이아민Korean label name (MFDS standard)

CAS No.chemical registry number: 5131-58-8
EC No.EU chemical inventory number: 225-876-3
DTXSIDUS EPA chemical ID: DTXSID1025770
DTXCIDUS EPA compound ID: DTXCID005770

IUPAC: 4-Nitrobenzene-1,3-diamine
Molecular formula: C6H7N3O2
Molecular weight: 153.141 g/mol

Measured properties

Appearance: 4-nitro-1,3-benzenediamine appears as orange prisms with blue luster or yellow crystalline solid. (NTP, 1992) · Orange solid, [HSDB] Orange solid with blue luster or yellow solid, [CAMEO] Yellow or brown crystalline powder, [Alfa Aesar MSDS]
Melting point: 322 °F (NTP, 1992) · 161 °C
Solubility: less than 1 mg/mL at 68.9 °F (NTP, 1992)
Melting/freezing point: 161 ℃
Water solubility: 24850 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): 0.2
Molecular weight: 153.139

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Dye1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 2 eye studies are on record.

Classed as highly irritating3

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 6 studies

High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to other guideline: as below
SkinSens1
Skin Sensitization · QSAR Predicted
High Frequency of Sensitization
skin sensitisation · Screening · according to other guideline: As mentioned below
Severe Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: as below according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to