4-NITRO-O-PHENYLENEDIAMINE

4-nitro-1,2-phenylenediamine is the primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. It is a C-nitro compound and a primary amino compound. It is functionally related to a 1,2-phenylenediamine.

Source: PubChem

US FDA substance register · UNII 5A9AX7Y0TT · registered name 4-NITRO-O-PHENYLENEDIAMINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Restricted

South Korea · Taiwan · United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · Taiwan FDA cosmetic ingredients · Taiwan FDA cosmetic regulations · UK cosmetics regulations (OPSS)

ASEAN

• Field of application and/or use : Hair dye substance in oxidative hair dye products. Use for dyeing eyelashes and eyebrows is not permitted.
• Other limitations and requirements : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5% Indonesia only : After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.1% The direction for use “wear suitable gloves” must be included in label or leaflet text.
• Conditions of use and warning which must be printed on the labels : The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary “black henna” tattoo in the past Do not use to dye eyelashes or eyebrows

China

• Maximum concentration : 0.5%

European Union

• Product Type, body parts : Hair dye substance in oxidative hair dye products
• Other : (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed '0,5%
• Wording of conditions of use and warnings : To be printing on the label: Hair colorants can cause severe allergic reactions.

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex III (restricted substances), entry 240 · applies to Hair dye substance in oxidative hair dye products

Source: EU restricted substances (Annex III)

Restriction Annex III/240 · Other restriction: ban substances that deplete the ozone layer · SCCS opinion: Opinion on 4-Nitro-o-phenylenediamine

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments - 2004/2005

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of 2-Nitro-p-Phenylenediamine and 4-Nitro-o-Phenylenediamine

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report: Amended Safety Assessment of 4-Nitro-o-Phenylenediamine as used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)