Are there usage precautions?

미생물 증식 억제 (추천 피부타입: 모든 피부 타입)

All ingredients

Ingredient Dictionary

5-BROMO-5-NITRO-1,3-DIOXANE

Korean limit: 0.1%

Definition

5-Bromo-5-Nitro-1,3-Dioxane is the substituted cyclic ether that conforms to the formula:

US FDA substance register · UNII U184I9QBNM · registered name 5-BROMO-5-NITRO-1,3-DIOXANE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Restricted: South Korea · Taiwan
Allowed preservative: Taiwan · United Kingdom

Source: Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information · ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.1%
Other limitations and requirements : Only products RINSE to n. Avoid formation of nitrosamines

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.1%
Other limitations and requirements : Rinse-off products only Avoid formation of nitrosamines

Canada

Conditions of Use by product type : (a) Not permitted in cosmetics that contain amines or amides. (b) Other cosmetics
Maximum Concentration Permitted : (b) 0.1%

China

Maximum concentration : 0.1%

European Union

Product Type, body parts : Rinse-off products
Maximum concentration in ready for use preparation : 0.1%
Other : Avoid formation of nitrosamines

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 20 · maximum concentration 0.1% · applies to Rinse-off products

Source: EU allowed preservatives (Annex V)

Restriction V/20 · SCCS opinion: A Clarification on the Formaldehyde and para-Formaldehyde Entry in Directive 76/768/EEC on cosmetic products; Opinion on The Determination of certain Formaldehyde Releasers in Cosmetic Products; SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances

Source: EU CosIng ingredient list

Reviewed by CIR: Annual Review of Cosmetic Ingredient Safety Assessments: 2007-2010

Source: US Cosmetic Ingredient Review (CIR)

Reviewed by CIR: Final Report on the Safety Assessment of 5-Bromo-5-Nitro-1,3-Dioxane

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

5-BROMO-5-NITRO-1,3-DIOXANEINCI1,3-Dioxane, 5-bromo-5-nitro-Synonym5-브로모-5-나이트로-1,3-디옥산Korean label name (MFDS standard)5-BROMO-5-NITRO-1,3 DIOXANESynonym

CAS No.chemical registry number: 30007-47-7
EC No.EU chemical inventory number: 250-001-7
DTXSIDUS EPA chemical ID: DTXSID1044560
DTXCIDUS EPA compound ID: DTXCID9024560

IUPAC: 5-Bromo-5-nitro-1,3-dioxane
Molecular formula: C4H6BrNO4
Molecular weight: 211.999 g/mol

What products actually use it for

What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as moderate1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

SkinSens1
Skin Sensitization · QSAR Predicted
Category 6.5B (Category 1)
Skin Sensitization · Read Across
Category 6.3A (Category 2)
Skin Irritation · Read Across
Category 6.4A (Category 2A)
Eye Irritation · Read Across