What is this ingredient?

미국 FDA 물질 등록 · UNII 20E75SVO7A · 등록명 7-ETHYLBICYCLOOXAZOLIDINE · 단일 화학물질

All ingredients

Ingredient Dictionary

7-ETHYLBICYCLOOXAZOLIDINE

Definition

US FDA substance register · UNII 20E75SVO7A · registered name 7-ETHYLBICYCLOOXAZOLIDINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

7-Ethylbicyclooxazolidine is the heterocyclic compound that conforms to the formula:

Cosmetic roles

Stops microbes growing in the productPRESERVATIVE

Safety & regulatory references

Allowed preservative: United Kingdom

Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · Taiwan FDA cosmetic ingredients · UK cosmetics regulations (OPSS)

Argentina · Brazil

Maximum concentration permitted at final product : 0.3%
Other limitations and requirements : Prohibited in oral care products that come into contact with mucous

ASEAN

Maximum authorised concentration in the finished cosmetic product : 0.3%
Other limitations and requirements : Prohibited in oral hygiene products and in products intended to come into contact with mucous membranes

Taiwan

0.3%

China

Maximum concentration : 0.3%

European Union

Maximum concentration in ready for use preparation : 0.3%
Other : Not to be used in oral products and in products applied on mucous membranes

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

EU Cosmetics Regulation, Annex V (allowed preservatives), entry 49 · maximum concentration 0.3%

Source: EU allowed preservatives (Annex V)

Restriction V/49 · SCCS opinion: SCIENTIFIC ADVICE ON the threshold for the warning ‘contains formaldehyde’ in Annex V, preamble point 2 for formaldehyde-releasing substances

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Names & identifiers

7-ETHYLBICYCLOOXAZOLIDINEINCI1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-Synonym7-에틸바이사이클로옥사졸리딘Korean label name (MFDS standard)

CAS No.chemical registry number: 7747-35-5
EC No.EU chemical inventory number: 231-810-4
DTXSIDUS EPA chemical ID: DTXSID3029289
DTXCIDUS EPA compound ID: DTXCID309289

IUPAC: 7a-Ethyldihydro-1H,3H,5H-[1,3]oxazolo[3,4-c][1,3]oxazole
Molecular formula: C7H13NO2
Molecular weight: 143.186 g/mol

Measured properties

Appearance: liquid
Colour: colourless
pH: 10 ( 20 °C)
Melting/freezing point: 1 ℃
Initial boiling point and range: 187 ℃
Flash point: 79 ℃
Vapour pressure: 60.6 ㎩
Auto-ignition temperature: 230 ℃
Viscosity: 5.2 mPa S
Molecular weight: 143.19

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: KOSHA safety data sheets (Korea)

What products actually use it for

What the 8 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Preservative2
Solvent2
Lubricating agent1
Processing aids not otherwise specified1
Surfactant (surface active agent)1
Biocide1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 0 eye studies are on record.

Classed as highly irritating2Classed as low1

The study conclusions largely agree (67%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Sh
Skin Sensitization · Authoritative