N-acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
How much products actually contain
No product states its amount yet.
Of the products containing it, 2 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
3 of 3 confirmed · likeliest to carry enough first
Definition
N-acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. It has a role as a ferroptosis inhibitor, a geroprotector, an antioxidant, an antiinfective agent, an antiviral drug, a radical scavenger, a vulnerary, an antidote to paracetamol poisoning, a mucolytic and a human metabolite. It is a N-acetyl-L-amino acid, an acetylcysteine and a L-cysteine derivative. It is a conjugate acid of a N-acetyl-L-cysteinate.
Source: PubChem
US FDA substance register · UNII WYQ7N0BPYC · registered name Acetylcysteine · single chemical substance
Cosmetic roles
Safety & regulatory references
- Restricted
- South Korea · Taiwan
Source: MFDS (Korea) cosmetic regulatory information
Japan
- Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 9.0 g
- Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 9.0 g
- Maximum amount per 100 g (Cosmetics that may be used for mucosa) :
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
Reviewed by CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アセチルシステイン: 本品は、システイン(*)をアセチル化したものであり、次の化学式で表される。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 616-91-1
- EC No.EU chemical inventory number
- 210-498-3
- DTXSIDUS EPA chemical ID
- DTXSID5020021
- DTXCIDUS EPA compound ID
- DTXCID4021
- IUPAC
- N-Acetyl-L-cysteine
- Molecular formula
- C5H9NO3S
- Molecular weight
- 163.19 g/mol
Measured properties
- Appearance
- Solid · Crystals from water
- Odour
- SLIGHT ACETIC ODOR
- Melting point
- 109-110 · 109.5 °C
- Solubility
- 1 G IN 5 ML WATER, 4 ML ALC, PRACTICALLY INSOL IN CHLOROFORM & ETHER · Soluble in water, alcohol, hot isopropyl alcohol, methyl acetate, and ethyl acetate
- Stability
- Stable in ordinary light, stable at temp up to 120 °C, nonhygroscopic (oxidizes in moist air)
- pH
- 2 TO 2.75 (1 IN 100 ML) · 2~2.75 (1 IN 100 ML)
- Dissociation constant
- 9.52 (at 25 °C) · pKa= 3.24 (carboxylic acid moiety)
- Colour
- white
- Melting/freezing point
- 109 ℃
- Initial boiling point and range
- 371 ℃
- Vapour pressure
- 0.000011 ㎜Hg (@ 25 ℃, est.)
- Water solubility
- (200 g/L)
- Vapour density
- 5.63
- Relative density
- 1.48
- n-Octanol/water partition coefficient (Kow)
- -0.66 (est.)
- Molecular weight
- 163.21
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner3
- Antioxidant2
Source: US EPA CompTox dashboard
Related literature
- N-acetyl Cysteine Supplementation to Alleviate Skin Picking Disorder: A Case Report · 2024
- Effect Of Topical Application of N-Acetyl Cysteine and Vascular Endothelial Growth Factor on Cutaneous Wound Healing · 2024
- Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing · 2023
- Microneedle-mediated transdermal delivery of N-acetyl cysteine as a potential antidote for lewisite injury · 2023
- Successful treatment of non-healing pressure ulcers with topical n-acetyl cysteine. · 2015
Linked databases 21
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information 2 3
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · Korean · English · Japanese · Chinese