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Ingredients

Ingredient Dictionary

ACETYL CYSTEINE

N-acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.

Molecular structure

How much products actually contain

No product states its amount yet.

Of the products containing it, 2 list it before the 1% line and 1 after it (usually 1% or less).

Products using this ingredient

3 of 3 confirmed · likeliest to carry enough first

Definition

N-acetyl-L-cysteine is an N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. It has a role as a ferroptosis inhibitor, a geroprotector, an antioxidant, an antiinfective agent, an antiviral drug, a radical scavenger, a vulnerary, an antidote to paracetamol poisoning, a mucolytic and a human metabolite. It is a N-acetyl-L-amino acid, an acetylcysteine and a L-cysteine derivative. It is a conjugate acid of a N-acetyl-L-cysteinate.

Source: PubChem

US FDA substance register · UNII WYQ7N0BPYC · registered name Acetylcysteine · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Slows spoilage by oxygenANTIOXIDANTKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Restricted
South Korea · Taiwan

Source: MFDS (Korea) cosmetic regulatory information

Japan

  • Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : 9.0 g
  • Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 9.0 g
  • Maximum amount per 100 g (Cosmetics that may be used for mucosa) :

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

Reviewed by CIR: Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name アセチルシステイン: 本品は、システイン(*)をアセチル化したものであり、次の化学式で表される。

Source: JCIA labelling names (Japan)

Names & identifiers

ACETYL CYSTEINEINCI아세틸시스테인Korean label name (MFDS standard)アセチルシステインJapanese labelling name
CAS No.chemical registry number
616-91-1
EC No.EU chemical inventory number
210-498-3
DTXSIDUS EPA chemical ID
DTXSID5020021
DTXCIDUS EPA compound ID
DTXCID4021
IUPAC
N-Acetyl-L-cysteine
Molecular formula
C5H9NO3S
Molecular weight
163.19 g/mol

Measured properties

Appearance
Solid · Crystals from water
Odour
SLIGHT ACETIC ODOR
Melting point
109-110 · 109.5 °C
Solubility
1 G IN 5 ML WATER, 4 ML ALC, PRACTICALLY INSOL IN CHLOROFORM & ETHER · Soluble in water, alcohol, hot isopropyl alcohol, methyl acetate, and ethyl acetate
Stability
Stable in ordinary light, stable at temp up to 120 °C, nonhygroscopic (oxidizes in moist air)
pH
2 TO 2.75 (1 IN 100 ML) · 2~2.75 (1 IN 100 ML)
Dissociation constant
9.52 (at 25 °C) · pKa= 3.24 (carboxylic acid moiety)
Colour
white
Melting/freezing point
109 ℃
Initial boiling point and range
371 ℃
Vapour pressure
0.000011 ㎜Hg (@ 25 ℃, est.)
Water solubility
(200 g/L)
Vapour density
5.63
Relative density
1.48
n-Octanol/water partition coefficient (Kow)
-0.66 (est.)
Molecular weight
163.21

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

  • Softener and conditioner3
  • Antioxidant2

Source: US EPA CompTox dashboard

Related literature

Linked databases 21