- Lines D
- Amount studies used
- as formulated
- When
- morning and evening
- Irritation
- low
Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.
How much products actually contain
115 products state the amountmedian 0.000001%
- under 0.01% 113
- 0.01–0.1% 2
- 0.1–1% 0
- 1% or more 0
Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.
Of the products containing it, 265 list it before the 1% line and 826 after it (usually 1% or less).
Clinical evidence grade by skin concern
- D
- lab work or a record only
Products using this ingredient
12 of 1,089 confirmed · likeliest to carry enough first · See all 1,089
SidmoolMega Peptide Eco Hydro Soothing Cream0.05% stated
S.NATUREAqua Collagen Peptide Triple Gel Essence0.005% stated
COSRXThe 6 Peptide Skin Booster Serum0.0005% stated
COSRXThe 6 Peptide Skin Booster Serum 150ml0.0005% stated
COSRXThe 6 Peptide Skin Booster Serum0.0005% stated
COSRXCOSRX The 6 Peptide Skin Booster Serum0.0005% stated
AIDAAIDA Pro-Peptide Eye Lift Booster Cream0.00015% stated
ESFOLIOEsfolio Peptide Collagen Cream 70g0.00001% stated
ESFOLIOEsfolio Peptide Collagen Toner 180ml0.00001% stated
ESFOLIOEsfolio Peptide Collagen Serum0.00001% stated
ESFOLIOEsfolio Peptide Collagen Eye Cream 30g0.00001% stated
TRU.HYAL100Tru.Barrier Repair Cream0.00001% stated
Definition
US FDA substance register · UNII L4EL31FWIL · registered name Acetyl Hexapeptide-8 Amide · protein
Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues
Cosmetic roles
Safety & regulatory references
Reviewed by CIR: Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アセチルヘキサペプチド－８: 本品は、アルギニン（＊）、メチオニン（＊）及びグルタミン酸（＊）からなる合成ヘキサペプチドのアセチル化物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 616204-22-9
- DTXSIDUS EPA chemical ID
- DTXSID201021291
- DTXCIDUS EPA compound ID
- DTXCID101506341
- IUPAC
- N-[(3S)-3-Acetamido-5-carboxypent-1-en-2-yl]-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
- Molecular formula
- C35H62N14O11S
- Molecular weight
- 887.03 g/mol
What products actually use it for
What the 4 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner2
- Humectant2
Source: US EPA CompTox dashboard
Related literature
- Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis · 2023
- Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics · 2025
- Acetyl Hexapeptide-8 in Cosmeceuticals—A Review of Skin Permeability and Efficacy · 2025
- Efficacy of Acetyl Hexapeptide-8 Ampoule on Improvement of Elasticity in C3H Mice Skin · 2022
- Quantitation of Acetyl Hexapeptide-8 in Cosmetics by Hydrophilic Interaction Liquid Chromatography Coupled to Photo Diode Array Detection · 2021
Linked databases 13
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary 2
- MFDS (Korea) cosmetic ingredient register 2
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US Cosmetic Ingredient Review (CIR) 2
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata 2