Oxaceprol is an L-proline derivative that is L-proline substituted by acetyl and hydroxy groups at positions 1 and 4R, respectively.
How much products actually contain
No product states its amount yet.
Of the products containing it, 0 list it before the 1% line and 1 after it (usually 1% or less).
Products using this ingredient
1 of 1 confirmed · likeliest to carry enough first
Definition
US FDA substance register · UNII Q0XV76B96L · registered name OXACEPROL · single chemical substance
Oxaceprol is an L-proline derivative that is L-proline substituted by acetyl and hydroxy groups at positions 1 and 4R, respectively. It is an anti-inflammatory drug used for the management of osteoarthritis. It has a role as an anti-inflammatory drug and a dermatologic drug. It is a member of acetamides, a pyrrolidinemonocarboxylic acid, a monohydroxypyrrolidine and a L-proline derivative.
Source: PubChem
Cosmetic roles
Safety & regulatory references
Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アセチルヒドロキシプロリン: 本品は、ヒドロキシプロリン（＊）のアセチル化物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 33996-33-7
- EC No.EU chemical inventory number
- 251-780-6
- DTXSIDUS EPA chemical ID
- DTXSID2046410
- DTXCIDUS EPA compound ID
- DTXCID0026410
- IUPAC
- (4R)-1-Acetyl-4-hydroxy-L-proline
- Molecular formula
- C7H11NO4
- Molecular weight
- 173.168 g/mol
Measured properties
- Solubility
- >26 [ug/mL] (The mean of the results at pH 7.4)
Values measured on the substance itself, not a specification for a commercial raw material.
Source: PubChem
What products actually use it for
What the 13 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner8
- Humectant5
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
2 skin studies and 2 eye studies are on record.
The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 4 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) 1992-07-17 according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to - Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) 1992-07-17 according to EU Method B.6 (Skin Sensitisation) - Ambiguous
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1987-02-24 according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to - Corrosive or Irritation Persists for > 21 days
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) 1981 according to
Source: US EPA CompTox dashboard
Related literature
- 医用工学部研究論文 Effect of high functional lipid lipo-capsule contaning acetyl hydroxyproline on animal skin disease · 2011
- [Action of N-acetyl-hydroxyproline in the treatment of cutaneous ulcerative lesions]. · 1979
- 50635 Tolerance and Effectiveness of a Formulation Containing Acetyl Hydroxyproline on Sensitive Skin · 2024
Linked databases 16
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- PubChem 2
- Tlooto literature search 2 3
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English