Ingredient Dictionary

ACETYLSALICYLIC ACID

Aspirin can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.

Definition

Aspirin can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.

Source: PubChem

US FDA substance register · UNII R16CO5Y76E · registered name Aspirin · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Acetylsalicylic Acid is the organic compound that conforms to the formula:

Cosmetic roles

Helps dead skin come awayEXFOLIATING

Safety & regulatory references

Banned: Canada

Source: Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

More data — names, identifiers, properties, test records, literature

Names & identifiers

ACETYLSALICYLIC ACIDINCI아세틸살리실릭애씨드Korean label name (MFDS standard)Benzoic acid, 2-(acetyloxy)-Synonym

CAS No.chemical registry number: 50-78-2
EC No.EU chemical inventory number: 200-064-1
DTXSIDUS EPA chemical ID: DTXSID5020108
DTXCIDUS EPA compound ID: DTXCID50108

IUPAC: 2-(Acetyloxy)benzoic acid
Molecular formula: C9H8O4
Molecular weight: 180.159 g/mol

Measured properties

Appearance: Acetylsalicylic acid appears as odorless white crystals or crystalline powder with a slightly bitter taste. (NTP, 1992) · Odorless, colorless to white, crystal-line powder. [aspirin] [Note: Develops the vinegar-like odor of acetic acid on contact with moisture.]
Odour: Odorless, but in moist air it is gradually hydrolyzed and acquires odor of acetic acid · Odorless [Note: Develops the vinegar-like odor of acetic acid on contact with moisture].
Boiling point: 284 °F at 760 mmHg (decomposes) (NTP, 1992) · 140 °C
Melting point: 275 °F (NTP, 1992) · 138-140
Solubility: less than 1 mg/mL at 73 °F (NTP, 1992) · 10 mg/mL
Density: 1.4 (NTP, 1992) - Denser than water, will sink · 1.40
Stability: STABLE IN DRY AIR, IN MOIST AIR IT IS GRADUALLY HYDROLYZED INTO SALICYLIC AND ACETIC ACIDS · In aqueous solutions, aspirin is most stable at a pH of 2-3, less stable at a pH of 4-8, and least stable at a pH less than 2 or greater than 8. In a saturated aqueous solution at a pH of 5-7, aspirin is almost completely hydrolyzed within 1 week at 25 °C.
Dissociation constant: 3.47 · 3.5
Colour: white
Melting/freezing point: 135 ℃
Flash point: 250 ℃(1atm)
Vapour pressure: 0.0000252 ㎜Hg (25℃)
Water solubility: 4600 ㎎/ℓ (25℃)
Relative density: 1.4
n-Octanol/water partition coefficient (Kow): 1.19
Molecular weight: 180.16

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Pharmaceutical (EPA)1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

6 skin studies and 3 eye studies are on record.

Classed as low4

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 9 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to EU Method B.6 (Skin Sensitisation)
Classification not possible
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) equivalent or similar to
Not classified
Skin Irritation · Screening
Category 6.3B (Category 3)
Skin Irritation · Read Across
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across
Category 2A
Eye Irritation · Screening