Aspirin can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.
定义
Aspirin can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts.
来源: PubChem
美国FDA 物质登记 · UNII R16CO5Y76E · 登记名称 Aspirin · 单一化学物质
Acetylsalicylic Acid is the organic compound that conforms to the formula:
化妆品中的作用
帮助脱落老废角质EXFOLIATING
安全与法规参考
- 禁用
- 加拿大
来源: 加拿大禁用·限用成分清单 · 韩国食药处 化妆品法规信息
未列入韩国有毒物质 GHS 分类 · 现有化学物质
加拿大化妆品成分热点清单 · 禁止用于化妆品
来源: 加拿大禁用·限用成分清单
详细资料——标示名称、识别编号、物性、试验记录、文献
别名和识别信息
ACETYLSALICYLIC ACIDINCI아세틸살리실릭애씨드韩国标示名称（食药处标准名）Benzoic acid, 2-(acetyloxy)-同义名
- CAS No.化学物质登记号
- 50-78-2
- EC No.欧盟化学品目录编号
- 200-064-1
- DTXSID美国EPA化学品编号
- DTXSID5020108
- DTXCID美国EPA化合物编号
- DTXCID50108
- IUPAC
- 2-(Acetyloxy)benzoic acid
- 分子式
- C9H8O4
- 分子量
- 180.159 g/mol
实测物性
- 性状
- Acetylsalicylic acid appears as odorless white crystals or crystalline powder with a slightly bitter taste. (NTP, 1992) · Odorless, colorless to white, crystal-line powder. [aspirin] [Note: Develops the vinegar-like odor of acetic acid on contact with moisture.]
- 气味
- Odorless, but in moist air it is gradually hydrolyzed and acquires odor of acetic acid · Odorless [Note: Develops the vinegar-like odor of acetic acid on contact with moisture].
- 沸点
- 284 °F at 760 mmHg (decomposes) (NTP, 1992) · 140 °C
- 熔点
- 275 °F (NTP, 1992) · 138-140
- 溶解性
- less than 1 mg/mL at 73 °F (NTP, 1992) · 10 mg/mL
- 密度
- 1.4 (NTP, 1992) - Denser than water, will sink · 1.40
- 稳定性
- STABLE IN DRY AIR, IN MOIST AIR IT IS GRADUALLY HYDROLYZED INTO SALICYLIC AND ACETIC ACIDS · In aqueous solutions, aspirin is most stable at a pH of 2-3, less stable at a pH of 4-8, and least stable at a pH less than 2 or greater than 8. In a saturated aqueous solution at a pH of 5-7, aspirin is almost completely hydrolyzed within 1 week at 25 °C.
- 解离常数
- 3.47 · 3.5
- 颜色
- 白色
- 熔点/凝固点
- 135 ℃
- 闪点
- 250 ℃(1atm)
- 蒸气压
- 0.0000252 ㎜Hg (25℃)
- 溶解度
- 4600 ㎎/ℓ (25℃)
- 比重
- 1.4
- 正辛醇/水分配系数（Kow）
- 1.19
- 分子量
- 180.16
这是对物质本身测得的数值。韩国安全保健公团（KOSHA）的资料仅供编写和审核安全数据表参考，并非原料商品的规格。
来源: PubChem · 韩国安全保健公团 安全数据表
产品实际使用的用途
刺激与致敏试验记录
记录有皮肤试验 6 项、眼部试验 3 项。
归类为低4 项
试验结论基本一致（100%）。 这是对原料本身的试验记录，与成品中所含浓度下的刺激性不同。
查看全部 9 项试验
- Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to EU Method B.6 (Skin Sensitisation) - Classification not possible
Skin Sensitization · Screening - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) equivalent or similar to - Not classified
Skin Irritation · Screening - Category 6.3B (Category 3)
Skin Irritation · Read Across - Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to - Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Category 2A
Eye Irritation · Screening
来源: 美国EPA CompTox
相关文献
- Oral acetylsalicylic acid and prevalence of actinic keratosis. · 2014
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