Fluorescein (lactone form) is a xanthene dye that is highly fluorescent, detectable even when present in minute quantities.
Definition
Fluorescein (lactone form) is a xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy. It has a role as a radioopaque medium and a fluorescent dye. It is a polyphenol, a gamma-lactone, a xanthene dye, an oxaspiro compound, an organic heteropentacyclic compound and a member of 2-benzofurans. It is functionally related to a fluorescein (acid form).
Source: PubChem
US FDA substance register · UNII TPY09G7XIR · registered name Fluorescein · single chemical substance
Acid Yellow 73 is classed chemically as a fluoran colour. It conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Banned
- Argentina · ASEAN · Brazil · European Union
- Restricted or banned
- China
Source: MFDS (Korea) cosmetic regulatory information
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
Restriction II/1332 (when used as a substance in hair dye products)
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 2321-07-5
- EC No.EU chemical inventory number
- 219-031-8
- DTXSIDUS EPA chemical ID
- DTXSID0038887
- DTXCIDUS EPA compound ID
- DTXCID8018887
- IUPAC
- 3',6'-Dihydroxy-3H-spiro[[2]benzofuran-1,9'-xanthen]-3-one
- Molecular formula
- C20H12O5
- Molecular weight
- 332.311 g/mol
Measured properties
- Appearance
- Fluorescein appears as yellow amorphous solid or orange-red crystals. Latter have greenish-yellow fluorescence by reflected light. Insoluble in water. Soluble in dilute aqueous bases. Very dilute alkaline solutions exhibit intense, greenish-yellow fluorescence by reflected light. Low toxicity. May be sensitive to prolonged exposure to light. · Yellowish-red to red solid, [Merck Index] Orange powder, [MSDSonline]
- Melting point
- Decomposes at 554 °F. In sealed tube, melts at 597-601 °F with decomposition (NTP, 1992) · 315 dec °C
- Solubility
- Insoluble (NTP, 1992) · 600 mg/mL (sodium salt)
- Molecular weight
- 332.34
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Dye5
- Solvent1
Source: US EPA CompTox dashboard
Related literature
Linked databases 11
- Australian Industrial Chemicals Inventory (AICIS)
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic regulatory information 2 3 4
- PubChem 2
- Tlooto literature search
- US EPA CompTox dashboard 2
- US FDA Unique Ingredient Identifier (UNII)