Are there usage precautions?

안티에이징 효과 (추천 피부타입: 모든 피부타입 가능(민감성 피부 유의))

Ingredient Dictionary

ADENOSINE

Adenosine is a ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a betaN9-glycosidic bond.

Clinical evidence

Lines B-

Set amount: 0.04% (MFDS anti-wrinkle functional ingredient)
When: morning and evening
Irritation: low

Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.

ADENOSINE Molecular structure — Molecular structure

How much products actually contain

8 products state the amountmedian 0.04%100% at or above the amount studies used (0.04% (MFDS anti-wrinkle functional ingredient))

under 0.01% 0
0.01–0.1% 7
0.1–1% 1
1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

1,420 products are filed with Korea's MFDS as wrinkle care functional cosmetics, which fixes it at the notified amount (0.04%) or more.

Of the products containing it, 866 list it before the 1% line and 2,969 after it (usually 1% or less).

Where no amount is stated, a product listing it early reaches the study amount about 61% of the time, one listing it late about 50%.

Clinical evidence grade by skin concern

B: one or two randomised trials

2 references

Abella 2006, adenosine on wrinkles, placebo-controlled, 126 women
Korea MFDS, Regulation on the Review of Functional Cosmetics, Annex 4 notified ingredient (efficacy and amount approved together)

Products using this ingredient

12 of 3,820 confirmed · likeliest to carry enough first · See all 3,820

Definition

Adenosine is a ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a betaN9-glycosidic bond. It has a role as an analgesic, a vasodilator agent, an anti-arrhythmia drug, a human metabolite and a fundamental metabolite. It is a purines D-ribonucleoside and a member of adenosines. It is functionally related to an adenine.

Source: PubChem

US FDA substance register · UNII K72T3FS567 · registered name ADENOSINE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Keeps skin in good condition (CosIng catch-all)SKIN CONDITIONING

Safety & regulatory references

Reviewed by CIR: Safety Assessment of Adenosine as Used in Cosmetics

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name アデノシン: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

ADENOSINEINCI아데노신Korean label name (MFDS standard)アデノシンJapanese labelling name

CAS No.chemical registry number: 58-61-7
EC No.EU chemical inventory number: 200-389-9
DTXSIDUS EPA chemical ID: DTXSID1022558
DTXCIDUS EPA compound ID: DTXCID902558

IUPAC: Adenosine
Molecular formula: C10H13N5O4
Molecular weight: 267.245 g/mol

Measured properties

Appearance: Solid · Needles (from water +3/2)
Odour: Odorless · odourless
Melting point: 235.5 °C
Solubility: Water solubility increases by warming and lowering the pH · Insoluble in ethanol
pH: pH = 4.5-7.5 (solution of 3 mg/mL adenosine and 9 mg/mL sodium chloride in water)
Dissociation constant: pKa1 = 3.6, pKa2 = 12.4
Colour: white
Melting/freezing point: 235 ℃
Initial boiling point and range: 537.33 ℃
Flash point: 362.8 ℃
Vapour pressure: 0.00000000000000602 ㎜Hg
Water solubility: 22500 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): -1.05
Molecular weight: 267.24

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner3

Source: US EPA CompTox dashboard