What is this ingredient?

미국 FDA 물질 등록 · UNII VK98I9YW5M · 등록명 ADIPIC ACID DIHYDRAZIDE · 단일 화학물질

All ingredients

Ingredient Dictionary

ADIPIC ACID DIHYDRAZIDE

Definition

US FDA substance register · UNII VK98I9YW5M · registered name ADIPIC ACID DIHYDRAZIDE · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Listed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCERaises skin moistureMOISTURISING

Safety & regulatory references

Banned: Argentina · ASEAN · Brazil · Canada · China · European Union · South Korea · Taiwan

Source: ASEAN Cosmetic Directive · Health Canada Cosmetic Ingredient Hotlist · MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Health Canada Cosmetic Ingredient Hotlist · prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

Restriction II/200

Source: EU CosIng ingredient list

Reviewed by CIR: Final Report on the Safety Assessment of Adipic Acid Dihydrazide

Source: US Cosmetic Ingredient Review (CIR)

CIR reviewed this ingredient and flagged its status as: Insufficient data ingredients with no uses reported to FDA's Voluntary Cosmetic Registration Program (VCRP) (insufficient data or use not supported — CIR's own classification, not a full safety-as-used conclusion).

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Names & identifiers

ADIPIC ACID DIHYDRAZIDEINCI아디픽애씨드다이하이드라자이드Korean label name (MFDS standard)Hexanedioic acid, dihydrazideSynonym

CAS No.chemical registry number: 1071-93-8
EC No.EU chemical inventory number: 213-999-5
DTXSIDUS EPA chemical ID: DTXSID0044361
DTXCIDUS EPA compound ID: DTXCID8024361

IUPAC: Hexanedihydrazide
Molecular formula: C6H14N4O2
Molecular weight: 174.204 g/mol

Measured properties

Appearance: Dry Powder, Large Crystals, Liquid · solid
Colour: white
Melting/freezing point: 181.8 ℃
Flash point: &amp, gt, 150 ℃
Water solubility: 328700 ㎎/ℓ
n-Octanol/water partition coefficient (Kow): -2.05
Molecular weight: 174.20

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 24 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Chemical reaction regulator11
Hardener3
Processing aids not otherwise specified3
Humectant1
Deodorizer1
Adhesion/cohesion promoter1
Viscosity modifier1
Binder1

2 other uses

Plasticizer1
No specific technical function1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

4 skin studies and 1 eye studies are on record.

Classed as highly irritating2Classed as low4

The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 5 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
High Frequency of Sensitization
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
High Frequency of Sensitization
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to