Are there usage precautions?

피부 진정 효과가 뛰어나고 자극을 줄이며, 상처 치유를 돕는 성분입니다. 주로 보습제나 재생 크림에 사용되며, 민감한 피부에도 적합합니다. Urea-derived ingredient that promotes cell proliferation and exfoliation of dead skin cells, leading to faster healing and smoother skin, Promotes also barrier repair; modulates inflammatory cytokines, enhances hydration.

All ingredients

Ingredient Dictionary

ALLANTOIN

Allantoin is an imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.

Clinical evidence

Skin barrier D

Amount studies used: 0.1–2%
When: morning and evening
Irritation: low

Grades were set by reading this ingredient’s studies. They describe the ingredient, not every product that contains it.

ALLANTOIN Molecular structure — Molecular structure

How much products actually contain

4 products state the amountmedian 0.2%75% at or above the amount studies used (0.1–2%)

under 0.01% 1
0.01–0.1% 0
0.1–1% 3
1% or more 0

Amounts are mostly stated by products named after the ingredient, so they may lean towards token amounts.

Of the products containing it, 1,717 list it before the 1% line and 1,849 after it (usually 1% or less).

Where no amount is stated, a product listing it early reaches the study amount about 68% of the time, one listing it late about 5%.

Clinical evidence grade by skin concern

D: lab work or a record only

1 references

ESSENCE 2020, allantoin 6% phase 3: both primary endpoints missed, 169 patients

Products using this ingredient

12 of 3,549 confirmed · likeliest to carry enough first · See all 3,549

Definition

Allantoin is an imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen. It has a role as a vulnerary, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human metabolite. It is an imidazolidine-2,4-dione and a member of ureas. It is functionally related to a hydantoin. It is a tautomer of a 1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea.

Source: PubChem

US FDA substance register · UNII 344S277G0Z · registered name Allantoin · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Protects skin from outside irritantsSKIN PROTECTINGKeeps skin in good condition (CosIng catch-all)SKIN CONDITIONINGEases skin discomfortSOOTHING

Safety & regulatory references

Taiwan

Maximum concentration : 0.5%

Japan

Maximum amount per 100 g (Cosmetics not used for mucosa and to be washed away) : (0.50) g
Maximum amount per 100 g (Cosmetics not used for mucosa and not to be washed away) : 0.3 g
Maximum amount per 100 g (Cosmetics that may be used for mucosa) : (0.20) g

Source: MFDS (Korea) cosmetic regulatory information

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

Reviewed by CIR: Final Report of the Safety Assessment of Allantoin and its Related Complexes

Source: US Cosmetic Ingredient Review (CIR)

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name アラントイン: 本品は、次の化学式で表される複素環式化合物である。

Source: JCIA labelling names (Japan)

Names & identifiers

ALLANTOININCI알란토인Korean label name (MFDS standard)Urea, (2,5-dioxo-4-imidazolidinyl)-SynonymアラントインJapanese labelling name

CAS No.chemical registry number: 97-59-6
EC No.EU chemical inventory number: 202-592-8
DTXSIDUS EPA chemical ID: DTXSID3020043
DTXCIDUS EPA compound ID: DTXCID0043

IUPAC: N-(2,5-Dioxoimidazolidin-4-yl)urea
Molecular formula: C4H6N4O3
Molecular weight: 158.117 g/mol

Measured properties

Appearance: Dry Powder · Colorless to white odorless solid, [Hawley] White powder, [MSDSonline]
Odour: Odorless · Pleasant smelling
Melting point: 239 °C /Racemic form/ · MP: 230 °C (decomposes)
Solubility: Soluble in alcohol, methanol, pyridine · Soluble in ethanol, sodium hydroxide, insoluble in ethyl ether, methanol
pH: pH = 4.5 - 6 (5% in water, 20 °C) · 4.5 (4.5~6)
Colour: white
Melting/freezing point: 238 ℃
Vapour pressure: 0.00000000432 ㎜Hg
n-Octanol/water partition coefficient (Kow): -3.14
Decomposition temperature: 225-240 ℃
Molecular weight: 158.12

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 42 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Softener and conditioner27
Humectant13
Fragrance1
Preservative1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 3 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) equivalent or similar to