Ingredient Dictionary

AMBROXIDE

Ambroxan is a diterpenoid derived from sclareol that is responsible for the odour of ambergris (a solid, waxy, flammable substance produced in the digestive system of sperm whales).

How much products actually contain

No product states its amount yet.

Of the products containing it, 0 list it before the 1% line and 2 after it (usually 1% or less).

Products using this ingredient

2 of 2 confirmed · likeliest to carry enough first

Definition

Ambroxan is a diterpenoid derived from sclareol that is responsible for the odour of ambergris (a solid, waxy, flammable substance produced in the digestive system of sperm whales). It is a diterpenoid and an organic heterotricyclic compound.

Source: PubChem

US FDA substance register · UNII TD34B3O8M9 · registered name AMBROXIDE, (-)- · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Ambroxide is the heterocyclic compound that conforms to the formula:

Cosmetic roles

Gives the product a scentPERFUMINGListed as a fragrance-composition material (not a claim that it adds scent)FRAGRANCE

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

AMBROXIDEINCINaphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, [3aR-(3a.alpha.,5a.beta.,9a.alpha.,9b.beta.)]-Synonym

CAS No.chemical registry number: 6790-58-5
DTXSIDUS EPA chemical ID: DTXSID0047113
DTXCIDUS EPA compound ID: DTXCID8027113

IUPAC: (3aR,5aS,9aS,9bR)-3a,6,6,9a-Tetramethyldodecahydronaphtho[2,1-b]furan
Molecular formula: C16H28O
Molecular weight: 236.399 g/mol

Measured properties

Appearance: CBI, Liquid
Colour: white
Melting/freezing point: 73~77 ℃
Initial boiling point and range: 273.9 ℃
Flash point: 104.8 ℃
Vapour pressure: 0.00393 ㎜Hg (est.)
Water solubility: 2.436 ㎎/ℓ
Relative density: 0.939
Molecular weight: 236.39

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 35 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance31
Flavouring and nutrient2
Deodorizer2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 2 eye studies are on record.

Classed as low6

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 7 studies

Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (Adopted 12th May 1981) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) (Adopted in March 1984) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (Adopted 12th May 1981) according to
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (Adpoted in 12th May 1981) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) (Adopted in March 1984) according to
Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) according to EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay) according to EPA OPPTS 870.2600 (Skin Sensitisation)
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation) (Adopted in May 1981) according to EU Method B.6 (Skin Sensitisation) (Adopted in March 1984)
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) (Adopted February 24, 1987) according to
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · other guideline: 16 C.F.R. s 1500.42 Test for eye irritants. according to