Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring.
Definition
Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor, a cathepsin B inhibitor and a plant metabolite. It is a hydroxyflavone, a ring assembly and a biflavonoid.
Source: PubChem
US FDA substance register · UNII 9I1VC79L77 · registered name AMENTOFLAVONE · single chemical substance
Amentoflavone
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Names & identifiers
- CAS No.chemical registry number
- 1617-53-4
- DTXSIDUS EPA chemical ID
- DTXSID20167225
- DTXCIDUS EPA compound ID
- DTXCID1089716
- IUPAC
- 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- Molecular formula
- C30H18O10
- Molecular weight
- 538.464 g/mol
What products actually use it for
What the 2 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Bleaching agent1
- Antioxidant1
Source: US EPA CompTox dashboard
Related literature
- Selaginella tamariscina extract and amentoflavone ameliorate UVB-induced skin aging via AMPK activation. · 2026
- Amentoflavone mitigates UVB-induced epidermal photoaging by antagonizing PAR2-driven PI3K/Akt/FoxO6 oxidative-stress signaling. · 2026
- Analysis of Nonclinical Safety and Corneal Pain-Inducing Potential of Amentoflavone (AMT) in Adult Zebrafish (Danio rerio). · 2025
- Amentoflavone-Enriched Selaginella rossii Protects against Ultraviolet- and Oxidative Stress-Induced Aging in Skin Cells · 2022
- Amentoflavone as an Ally in the Treatment of Cutaneous Leishmaniasis: Analysis of Its Antioxidant/Prooxidant Mechanisms · 2021