Ingredient Dictionary

AMINOBUTYRIC ACID

Gamma-aminobutyric acid is a gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

How much products actually contain

No product states its amount yet.

Of the products containing it, 10 list it before the 1% line and 23 after it (usually 1% or less).

Products using this ingredient

12 of 33 confirmed · likeliest to carry enough first · See all 33

Definition

Gamma-aminobutyric acid is a gamma-amino acid that is butanoic acid with the amino substituent located at C-4. It has a role as a neurotransmitter, a signalling molecule, a Saccharomyces cerevisiae metabolite and a human metabolite. It is a monocarboxylic acid and a gamma-amino acid. It is functionally related to a butyric acid. It is a conjugate acid of a gamma-aminobutyrate. It is a tautomer of a gamma-aminobutyric acid zwitterion.

Source: PubChem

US FDA substance register · UNII 2ACZ6IPC6I · registered name .GAMMA.-AMINOBUTYRIC ACID · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Softens hairHAIR CONDITIONING

Safety & regulatory references

Other restriction: ban substances that deplete the ozone layer

Source: EU CosIng ingredient list

More data — names, identifiers, properties, test records, literature

Official labels & definitions

JCIA labelling name アミノ酪酸: 本品は、次の化学式で表されるアミノ酸である。

Source: JCIA labelling names (Japan)

Names & identifiers

AMINOBUTYRIC ACIDINCI아미노부티릭애씨드Korean label name (MFDS standard)Butanoic acid, 4-amino-Synonymアミノ酪酸Japanese labelling name

CAS No.chemical registry number: 56-12-2
EC No.EU chemical inventory number: 200-258-6
DTXSIDUS EPA chemical ID: DTXSID6035106
DTXCIDUS EPA compound ID: DTXCID4015106

IUPAC: 4-Aminobutanoic acid
Molecular formula: C4H9NO2
Molecular weight: 103.121 g/mol

Measured properties

Appearance: Solid · solid
Melting point: 203 °C
Solubility: 1300.0 mg/mL · 1.2 [ug/mL] (The mean of the results at pH 7.4)
Dissociation constant: 10.6
Colour: white
pH: 6.5-7.5
Melting/freezing point: 203 ℃
Vapour pressure: 0.0000000198 ㎜Hg (25 deg c)
Water solubility: 1300000 ㎎/ℓ (25 deg c)
n-Octanol/water partition coefficient (Kow): -3.17
Molecular weight: 103.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 6 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

No specific technical function2
Flavouring and nutrient2
Softener and conditioner2

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

2 skin studies and 2 eye studies are on record.

Classed as low1

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Category 6.3B (Category 3)
Skin Irritation · Read Across
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across