5-aminolevulinic acid hydrochloride is a hydrochloride that is the monohydrochloride of 5-aminolevulinic acid.
Definition
Aminolevulinic Acid HCl is the organic compound that conforms to the formula:
5-aminolevulinic acid hydrochloride is a hydrochloride that is the monohydrochloride of 5-aminolevulinic acid. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. It has a role as an antineoplastic agent, a photosensitizing agent, a dermatologic drug and a prodrug. It contains a 5-ammoniolevulinic acid.
Source: PubChem
US FDA substance register · UNII V35KBM8JGR · registered name AMINOLEVULINIC ACID HYDROCHLORIDE · single chemical substance
Cosmetic roles
Safety & regulatory references
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アミノレブリン酸ＨＣｌ: 本品は、次の化学式で表される有機化合物である。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 5451-09-2
- EC No.EU chemical inventory number
- 226-679-5
- DTXSIDUS EPA chemical ID
- DTXSID5045914
- DTXCIDUS EPA compound ID
- DTXCID3025914
- IUPAC
- 5-Amino-4-oxopentanoic acid--hydrogen chloride (1/1)
- Molecular formula
- C5H10ClNO3
- Molecular weight
- 167.59 g/mol
Measured properties
- Appearance
- liquid
- Colour
- colourless
- Melting/freezing point
- -144 ℃
- Initial boiling point and range
- 148.3 ℉(( at 760mmHg))
- Flash point
- 52 ℉
- Vapour pressure
- 100 ㎜Hg (( at 70.2° F), 237.87 (100° F))
- Water solubility
- 100 ( at 70° F) ㎎/ℓ
- Vapour density
- 1.11g/cm³ (air =1)
- Relative density
- 0.79 (water =1)
- n-Octanol/water partition coefficient (Kow)
- -0.77
- Auto-ignition temperature
- 867 ℉
- Viscosity
- 0.544
- Molecular weight
- 32.042
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: KOSHA safety data sheets (Korea)
What products actually use it for
What the 3 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner2
- Biocide1
Source: US EPA CompTox dashboard
Related literature
- Photodynamic Therapy as Palliative Therapy for Invasive Syringoid Eccrine Carcinoma of the Auricle: A Case Report · 2013
- Does ambient light contribute to the therapeutic effects of topical photodynamic therapy (PDT) using aminolevulinic acid HCl (ALA)? · 2007
- 'Stick'-ing it to AK · 2003
- Photodynamic therapy systems and applications · 2002
- Topical Aminolevulinic Acid HCl · 2000
Linked databases 16
- ChEBI
- ChEMBL
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata