Ingredient Dictionary

AMINOTRIMETHYLENE PHOSPHONIC ACID

[Nitrilotris(methylene)]trisphosphonic acid is a phosphonoacetic acid.

Definition

[Nitrilotris(methylene)]trisphosphonic acid is a phosphonoacetic acid.

US FDA substance register · UNII 1Y702GD0FG · registered name AMINOTRIS(METHYLENEPHOSPHONIC ACID) · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Binds metal ions to prevent spoilageCHELATING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

AMINOTRIMETHYLENE PHOSPHONIC ACIDINCI아미노트라이메틸렌포스포닉애씨드Korean label name (MFDS standard)Phosphonic acid, P,P′,P′′-[nitrilotris(methylene)]tris-Synonym

CAS No.chemical registry number: 6419-19-8
EC No.EU chemical inventory number: 229-146-5
DTXSIDUS EPA chemical ID: DTXSID2027624
DTXCIDUS EPA compound ID: DTXCID107624

IUPAC: [Nitrilotris(methylene)]tris(phosphonic acid)
Molecular formula: C3H12NO9P3
Molecular weight: 299.048 g/mol

Measured properties

Appearance: Liquid · CBI, Liquid
Boiling point: 105 °C @760 [mm Hg]
Melting point: 210 - 215 °C · -14 °C
Solubility: 1000 mg/mL at 25 °C
Density: 1.33 @ 20°C
Melting/freezing point: -14 ℃
Initial boiling point and range: 105 ℃(10.1 hPa)
Flash point: &amp, gt, 100 ℃
Vapour pressure: 101 ㎩ (25℃)
Water solubility: 0.61 g/㎖ (35℃)
Relative density: 1.33 (20℃)
n-Octanol/water partition coefficient (Kow): -3.53
Viscosity: (11.08cPs at 20℃)
Molecular weight: 299.07

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 14 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Corrosion inhibitor4
Chelating agent2
Anti-scaling agent2
Stabilizing agent2
Wrinkle resisting agent1
Dispersing agent1
Intermediate1
Oxidizing agent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

3 skin studies and 1 eye studies are on record.

Classed as low2

The study conclusions largely agree (100%). These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 4 studies

Category 6.3A (Category 2)
Skin Irritation · Read Across
Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · equivalent or similar to OECD Guideline 406 (Skin Sensitisation)
Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to
Category 6.4A (Category 2A)
Eye Irritation · Read Across