Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Definition
Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties. It has a role as a metabolite, an anti-inflammatory drug, an antineoplastic agent and an anti-HIV agent. It is a primary alcohol, a secondary alcohol, a labdane diterpenoid, a carbobicyclic compound and a gamma-lactone.
Source: PubChem
US FDA substance register · UNII 410105JHGR · registered name ANDROGRAPHOLIDE · single chemical substance
Cosmetic roles
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name アンドログラホリド: 本品は、次の化学式で表される二環式ジテルペンラクトンである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 5508-58-7
- EC No.EU chemical inventory number
- 226-852-5
- DTXSIDUS EPA chemical ID
- DTXSID3045980
- DTXCIDUS EPA compound ID
- DTXCID1025980
- IUPAC
- (3E,4S)-4-Hydroxy-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}oxolan-2-one
- Molecular formula
- C20H30O5
- Molecular weight
- 350.455 g/mol
What products actually use it for
What the 1 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Softener and conditioner1
Source: US EPA CompTox dashboard
Related literature
- Andrographolide analogues are agonists of the estrogen receptor alpha in vitro and in vivo. · 2026
- Prospects for developing dietary supplements with taxifolin and andrographolide · 2025
- Andrographolide: A Drug of Choice for Skin Carcinoma · 2024
- Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective · 2021
- Nanoencapsulation of Andrographolide Rich Extract for the Inhibition of Cervical and Neuroblastoma Cancer Cells. · 2020
Linked databases 17
- ChEBI
- ChEMBL
- China inventory of existing ingredients (IECIC)
- EU CosIng ingredient list 2
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- MFDS (Korea) cosmetic ingredient register 2
- NIST Chemistry WebBook
- PubChem
- Tlooto literature search 2 3 4 5
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Chinese