Ingredient Dictionary

ANISOLE

Anisole is a monomethoxybenzene that is benzene substituted by a methoxy group.

Definition

Anisole is a monomethoxybenzene that is benzene substituted by a methoxy group. It has a role as a plant metabolite.

Source: PubChem

US FDA substance register · UNII B3W693GAZH · registered name Anisole · single chemical substance

Source: US FDA Unique Ingredient Identifier (UNII)

Cosmetic roles

Gives the product a scentPERFUMING

Safety & regulatory references

Not classified under Korea’s toxic-substance GHS list · existing chemical substance

Source: Korea toxic substances GHS register (NIER)

More data — names, identifiers, properties, test records, literature

Names & identifiers

ANISOLEINCIBenzene, methoxy-Synonym

CAS No.chemical registry number: 100-66-3
EC No.EU chemical inventory number: 202-876-1
DTXSIDUS EPA chemical ID: DTXSID4041608
DTXCIDUS EPA compound ID: DTXCID2021608

IUPAC: Anisole
Molecular formula: C7H8O
Molecular weight: 108.14 g/mol

Measured properties

Appearance: Anisole appears as a clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent. · Liquid
Odour: SWEET ANISE-LIKE ODOR · Agreeable aromatic odor
Boiling point: 155.5 °C AT 760 MM HG · 153.00 to 155.00 °C. @ 760.00 mm Hg
Melting point: -37.3 °C · -37.5 °C
Solubility: SOLUBLE IN ALCOHOL AND ETHER · VERY SOLUBLE IN ACETONE
Density: 0.9956 AT 18 °C/4 °C · PER CENT IN SATURATED AIR: 0.41, DENSITY OF SATURATED AIR: 1.1 (AIR= 1)
Viscosity: 1.52 centipoise at 15 °C, 0.778 centipoise at 30 °C
Melting/freezing point: -38.5 ℃
Initial boiling point and range: 155 ℃
Flash point: 52 ℃(o.c.)
Vapour pressure: 0.47 ㎪ (at 25 C)
Vapour density: 3.7 ()
Relative density: 0.9961 ()
n-Octanol/water partition coefficient (Kow): 2.11
Auto-ignition temperature: 475 ℃
Molecular weight: 108.14

Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.

Source: PubChem · KOSHA safety data sheets (Korea)

What products actually use it for

What the 5 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.

Fragrance2
Flavouring and nutrient2
Solvent1

Source: US EPA CompTox dashboard

Irritation and sensitisation studies

5 skin studies and 3 eye studies are on record.

Classed as moderate1Classed as low1

The studies disagree (the most common conclusion covers 50%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.

See all 8 studies

Not likely to be sensitizing
skin sensitisation: in vivo (non-LLNA) · Screening · according to OECD Guideline 406 (Skin Sensitisation)
Moderate or Mild Irritation
skin irritation: in vivo · Screening · OECD Guideline 404 (Acute Dermal Irritation / Corrosion) according to EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion) according to
Category 6.3B (Category 3)
Skin Irritation · Read Across
Classification not possible
Skin Irritation · Screening
Classification not possible
Skin Sensitization · Screening
Studies Indicate No Significant Irritation
eye irritation: in vivo · Screening · OECD Guideline 405 (Acute Eye Irritation / Corrosion) according to EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion) according to
Classification not possible
Eye Irritation · Screening
Category 6.4A (Category 2A)
Eye Irritation · Read Across